This review of the diagnostic accuracy of visual inspection compared with biopsy (gold standard) for the diagnosis or oral cancer and oral potentially malignant dissorders included 18 studies. For malignant lesions the pooled sensitivity was 88% (95%CI; 73% to 95%) and specificity 81%(95%CI; 51% to 95%).
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This review of the evidence on the malignant transformation of oral proliferative verrucous leukoplakia included 17 mainly retrospective observational studies. The overall estimate for malignant transformation was 43.87% (95% CI; 31.93 to 56.13) but only 4 studies were at low risk of bias.
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In this blog Manás Dave looks at a review of the prevalence of human papilloma virus (HPV) in oral potentially malignant disorders (OPMD). Although 52 studies were included one in five OPMDs being HPV positive is not a substantial link so teh findings need to be interpreted cautiously.
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Marianne Dobson in her first blog for the Dental Elf takes a look at a systematic review looking at the main clinical features of proliferative verrucous leukoplakia
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