Anya Borissova summarises the therapeutic mechanisms of psilocybin in treatment-resistant depression and changes noticed in the amygdala and prefrontal cortex during emotional processing.
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Pascal Immanuel Michael summarises a recent RCT, which looks at how a single dose of the psychedelic Ayahuasca may help people with severe depression who have not benefited from more traditional treatment.
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Jodi Rintelman writes her debut elf blog on the first randomised controlled trial on the efficacy and safety of intranasal esketamine as an adjunctive treatment to antidepressants for treatment-resistant depression.
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Jessica Bone reports on a recent cross-sectional study that looks at the clinical correlates of augmentation/combination treatment strategies in major depressive disorder.
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Our #EvidenceLive team of bloggers report on a recent feasibility study of psilocybin for the treatment of refractory depression.
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Sarah McDonald reports on a meta-analysis published yesterday, which found that when compared with active treatment, mindfulness-based cognitive therapy resulted in a reduced risk of depressive relapse.
This blog also features a podcast interview with the lead author of the research, Professor Willem Kuyken.
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Sarah McDonald presents the results of the Tavistock Adult Depression Study; a pragmatic RCT of long-term psychoanalytic psychotherapy for treatment-resistant depression.
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Ioana Cristea reviews the NIHR-DC Highlight on cognitive therapies for depression, published online today, which summarises three NIHR-funded trials (REEACT, CoBalT and PREVENT) looking at cCBT, CBT and MBCT for depression in adults.
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Sarsha Wilson publishes her debut blog about a recent RCT on the efficacy, safety and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in later life.
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Sarah McDonald considers the findings of the CoBalT RCT long-term follow-up, which finds that CBT plus antidepressants are clinically and cost effective for treatment-resistant depression in primary care.
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