Omega-3 supplements for the prevention of psychosis: another trial shows no benefit, so is it time to move on?

Feature

David Mongan reports on a recent trial of omega-3 supplementation for the prevention of psychosis in people at ultra-high risk, which finds no evidence of a positive effect. He reflects on these findings and considers what’s next for the field.

[read the full story...]

The role of the gut microbiome in treatment-resistant schizophrenia

Feature

Nuala Murray explores a recent Australian case-control study that looks at the associations between changes in gut microbiota and schizophrenia diagnosis, treatment resistance, and clozapine response.

[read the full story...]

Antidepressants: what is the Smallest Worthwhile Difference?

Performance,Rating,Or,Customer,Feedback,,Credit,Score,Or,Satisfaction,Measurement,

Linda Gask summarises findings from a cross-sectional online survey that investigated the Smallest Worthwhile Difference necessary for individuals with depression to consider taking antidepressants.

[read the full story...]

Is anxiety a gateway to other mental health problems? Comorbidities with depression and other anxiety disorders

Results from the current study largely replicated findings from the NESDA dataset in demonstrating that those with comorbid anxiety and/or depression have more severe presentations that anxiety or depression alone.

Nina Higson-Sweeney summarises a study using data from the UK-based GLAD and COPING NBR cohorts to investigate factors associated with anxiety disorder comorbidity with anxiety and depression.

[read the full story...]

Clinical severity and instability as predictors for psychiatric hospitalisation: can one size fit all? 

Mental,Health,Disorder,Concept.,Bipolar,Disorder,Person.,Unstable,Psycho.,Layers

Florian Walter summarises a retrospective cohort study published in The Lancet Psychiatry that investigates whether early trajectories of clinical global impression severity can transdiagnostically predict later psychiatric hospitalisation.

[read the full story...]