Paul Heron from the Closing the Gap Network writes his debut blog about a 20‐year cohort study of physical morbidity and mortality in relationship to antipsychotic treatment in a huge group of people with schizophrenia in Finland.
[read the full story...]Antipsychotics and metabolic function in people with schizophrenia
Peter Haddad and Sami Ouanes review a network meta-analysis of the impact of antipsychotic drugs on metabolic function in people with schizophrenia.
[read the full story...]Are antidepressants safe? A new umbrella review of observational studies suggests they are, but we need more accurate data
Andrea Cipriani and Anneka Tomlinson scrutinise a brand new umbrella review of the associations between antidepressants and adverse health outcomes, which suggests that antidepressants are safe for most people who experience mental health difficulties.
[read the full story...]In adults with major depression, antidepressants may increase the risk of suicide
Douglas Badenoch explores a meta-analysis of follow-up data from clinical trials of antidepressants, which found a small but significant increase in suicide risk.
[read the full story...]Higher doses of antidepressants “not optimal”, according to new review
Jonathon Tomlinson considers his options as a GP supporting people with depression and complex needs, after reading a new systematic review and dose-response meta-analysis, which suggests that higher doses of antidepressants bring maximum side effects with only marginal gains.
[read the full story...]Antidepressants and weight gain: long-term population impact #SUSANAsurvey
Andrea Cipriani and Anneka Tomlinson summarise a 10-year cohort study of antidepressant use and incidence of weight gain.
They also launch their new SUSANA project: Survey for Understanding Side effects of ANtidepressants in Adults. Please take the SUSANA survey now!
[read the full story...]Antidepressant withdrawal: slower and lower tapering of SSRIs
A group of UCL Masters Students summarise a recent personal view by Mark Horowitz and David Taylor about tapering of SSRI treatment to mitigate antidepressant withdrawal symptoms.
[read the full story...]Pregnancy and bipolar disorder: international prescribing consensus?
Dean Connolly looks at an international study which asks: Is there consensus across evidence-based guidelines for the psychotropic drug management of bipolar disorder during the perinatal period?
[read the full story...]Dropping out of virtual reality exposure therapy for anxiety: comparison with in-vivo exposure therapy
Aislinn Bergin writes her debut elf blog on a recent meta-analytic examination of attrition in virtual reality exposure therapy for anxiety disorders.
[read the full story...]Mandibular advancement devices in obstructive sleep apnoea: side effects
21 studies mainly retrospective studies were included in this review of the dental and skeletal effects of mandibular advancement devices in treatment of obstructive sleep apnoea. while the findings suggest a number of potential side effects the quality of the available evidence in low.
[read the full story...]