Gemma Lewis and Glyn Lewis summarise a robust systematic review and meta-analysis investigating the incidence of symptoms when discontinuing or withdrawing from antidepressants. The data suggest that 8-14% of patients will experience antidepressant discontinuation symptoms, and for around 2% these symptoms will be severe.
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Michael Kalfas and Paul Leeks summarise a recent Danish study that assesses the risk of antidepressant-induced mania in patients with bipolar depression.
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Linda Gask summarises findings from a cross-sectional online survey that investigated the Smallest Worthwhile Difference necessary for individuals with depression to consider taking antidepressants.
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In this blog, UCL MSc students consider an RCT published in the New England Journal of Medicine, which suggests that psilocybin-assisted psychotherapy may help reduce depression in people with severe and enduring illness, but side effects are common and more research is needed to look into longer term effects.
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Steven Parkes considers a randomised controlled trial exploring the satisfaction and side effects of gameChange, a virtual reality intervention targeting anxiety in every day situations for patients with psychosis.
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Cara Richardson and Stephanie Allan summarise a recent paper focusing on the growing field of digital psychiatry and the future of apps, social media, chatbots, and virtual reality.
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This review of the evidence on possible association between locally delivered nicotine replacement therapy(NRT) and oral side effects included 28 RCTs. Most of the RCTs were at high risk of bias mainly because of allocation concealment concerns. Reported oral side effects including oral soreness, gastric reflux or vomiting, and mouth or throat irritation.
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In his debut blog, Franco De Crescenzo summarises a narrative review that finds good evidence for the short-term pharmacological treatment of ADHD.
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Mark Horowitz and Joanna Moncrieff consider a new #ActiveIngredientsMH review published today in The Lancet Psychiatry, which looks at the knowns and unknowns of antidepressant treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action.
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Mark Horowitz considers a recent article written by Adele Framer, Founder of SurvivingAntidepressants.org, which describes how best to help people who are tapering off antidepressants.
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