Omega-3 supplements for the prevention of psychosis: another trial shows no benefit, so is it time to move on?

Feature

David Mongan reports on a recent trial of omega-3 supplementation for the prevention of psychosis in people at ultra-high risk, which finds no evidence of a positive effect. He reflects on these findings and considers what’s next for the field.

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The role of the gut microbiome in treatment-resistant schizophrenia

Feature

Nuala Murray explores a recent Australian case-control study that looks at the associations between changes in gut microbiota and schizophrenia diagnosis, treatment resistance, and clozapine response.

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The many faces of mental disorders

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Yuri Milaneschi discusses new research on the structure and presentation of mental health disorders, which suggests that although there are many different faces of major mental disorders, some of these faces are far more common than others.

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Childhood neglect: the neglected trauma? 

Featured

Dhea Bengardi summarises a systematic review exploring the prevalence of different types of neglect across a wide variety of mental health conditions.

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KarXT: an innovative and promising treatment for schizophrenia

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Nicola Rizzo Pesci and Andrea Cipriani summarise findings from the EMERGENT-2 trial spotlighting a promising new drug treatment for schizophrenia.

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The influence of the menopause in first onset of mental illness

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Katie Marwick on a new UK Biobank study which suggests that the two years either side of the final menstrual period represent a time of small increased risk for new onset bipolar and major depressive disorder.

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Mental illness is linked to being a victim and/or perpetrator of violence: time to face up to some inconvenient truths?

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Anabelle Paulino and Maya Ogonah summarise a recent Danish longitudinal study on the risk of violent victimisation and perpetration following the onset of mental illness.

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Just how good are antipsychotics at preventing relapse? Bridging the efficacy-effectiveness gap

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Samei Huda summarises a new network meta-analysis in the Lancet Psychiatry on the efficacy and effectiveness of antipsychotics for schizophrenia in research settings, such as randomised controlled trials, versus real-world and clinical settings.

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Lived experience perspectives of acceptance and commitment therapy for people with psychosis

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Charlotte Huggett reflects on a qualitative study exploring the perspectives of people with psychosis receiving Acceptance and Commitment Therapy following a first episode of psychosis.

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Brain-body health please: new research supports integrated physical and mental health care

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Athina Aruldass finds that management of serious neuropsychiatric disorders should acknowledge the importance of poor physical health and target restoration of both brain and body function.

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