Depression is common in patients with dementia and antidepressants are widely prescribed for this population although the evidence remains limited. This randomised controlled trial conducted by researchers at the Institute of Psychiatry in London and published in the Lancet, explored the safety and efficacy of two widely-used drugs (sertraline and mirtazapine) in patients with dementia and [read the full story…]
Older people who suffer from depression and executive dysfunction experience significant levels of disability and often don’t respond well to conventional drug treatments. This randomised controlled trial conducted by researchers from Weill Cornell Medical College in New York State, attempted to find out if problem-solving therapy is better than supportive therapy for reducing disability in older [read the full story…]
Many people with dementia experience pain, but often find it difficult to communicate this to their carers and the pain is therefore manifested as agitation instead. A randomised controlled trial published in the British Medical Journal looks at a systematic approach to the treatment of pain, to see if it can reduce agitation in people with [read the full story…]
There are increasing levels of interest in stepped care models to treat mental health problems in primary care. This randomised controlled trial investigated the effectiveness of a stepped care programme for treating depression and anxiety in 120 adults (aged 18-65 years with minor or major DSM-IV depressive and/or anxiety disorders) in general practice. Patients were [read the full story…]
Music therapy, when combined with standard treatment, is effective in helping people with depression, according to a small Finnish randomised controlled trial published in the August issue of the British Journal of Psychiatry. The research team from the University of Jyväskylä, led by Professor Jaakko Erkkilä and Professor Christian Gold, recruited 79 people aged between [read the full story…]
There is a need for a rapid-acting, non-injection, acute treatment for agitation in people with schizophrenia. This randomised (double-blind, placebo-controlled, parallel-group) controlled trial set out to evaluate the effectiveness and safety of inhaled loxapine for acute treatment of agitation in schizophrenia. The researchers recruited 344 adults with DSM-IV schizophrenia who were in good general health [read the full story…]
A research team from Umeå University in Sweden have published a randomised controlled trial that investigates the importance of pacing when delivering bibliotherapy for people with panic disorder, i.e. should patients be ‘prescribed’ a full book as therapy all at once, or should they be given separate chapters each week? The small trial randomised 28 [read the full story…]
Researchers from Manchester University have conducted one of the largest randomised controlled trials ever undertaken to investigate self-harm in adolescents. The trial published in the BMJ examined the effectiveness and cost-effectiveness of group therapy for self harm in young people by randomising 366 patients to: Manual based developmental group therapy programme specifically designed for adolescents [read the full story…]
Teenagers with depression sometimes do not respond to treatment with SSRI antidepressants and this inevitably leads to a higher cost of treatment. This randomised controlled trial (conducted by researchers from Kaiser Permanente Northwest in Portland, Oregon) set out to evaluate the incremental cost-effectiveness over 24 weeks of combined cognitive behavior therapy plus switch to a different antidepressant [read the full story…]
Major depressive disorder is a prevalent and debilitating condition in elderly patients. It is accompanied by circadian rhythm disturbances associated with impaired functioning of the suprachiasmatic nucleus, the biological clock of the brain. Circadian rhythm disturbances are common in the elderly. Suprachiasmatic nucleus stimulation using bright light treatment may, therefore, improve mood, sleep, and hormonal [read the full story…]
