Criteria to identify subgroups experiencing an at-risk mental state (ARMS) have been developed and are widely adopted internationally, but this has fueled recent debates about unintended stigmatising consequences of identifying and providing treatment to people at risk of psychosis. While the Early Detection and Intervention Evaluation 2 (EDIE-2) trial has shown that cognitive therapy (CT) [read the full story…]
Counselling is as effective as CBT for depression, according to a reanalysis of RCT data
In recent years, cognitive-behavioural therapy (CBT) has become the most widely delivered therapy for depression within the NHS. CBT interventions are recommended by NICE for people with mild, moderate and severe depression. By contrast, recent NICE guidelines recommend counselling only for people with persistent subthreshold depressive symptoms or mild to moderate depression who decline another [read the full story…]
D-cycloserine does not improve CBT for social anxiety disorder, but may accelerate early treatment gains
Clinical trials in the field of social anxiety to date have primarily focussed on the effect of either anxiolytic medication or cognitive behavioural therapy (CBT). At best these trials have demonstrated only moderate efficacy for either treatment independently (Davidson et al, 2004; Clark et al, 2003; Heimberg et al, 1998; Stein et al, 1998), and [read the full story…]
Largest RCT so far suggests that ketamine may be useful in the acute treatment of refractory depression
Major depression is a serious mental illness that often does not respond to mainstream drug treatment (antidepressants). In addition, there is usually a delay of 2-6 weeks before mood improves significantly. In situations like this, when at least two conventional antidepressants have been tried without success, depression is considered treatment-resistant. While multiple different strategies to [read the full story…]
Is gabapentin a promising drug for the treatment of alcohol dependence?
Alcohol misuse is responsible for about 4% of all deaths annually, and in the UK it costs the NHS more than £3 billion per year. A number of medications are currently licensed for the treatment of alcohol dependence. Unfortunately the medications don’t work for everyone and in the USA at least, fewer than 10% of [read the full story…]
‘Beating the Blues’ intervention shows promise for reducing depression and improving quality of life in older African Americans
This paper reports the findings of a study exploring a new approach to treating the symptoms of depression in older African Americans. This a group of the population with very high levels of general health care needs – the result of a combination of factors including the USA’s political and social history but also modern [read the full story…]
If I pay you, will you have your injection?
Getting patients to take their medication as prescribed is notoriously difficult. Regardless of condition only about 50% of patients adhere to prescribed regimes. This is particularly the case in chronic or complex conditions worldwide and improving this problem has the potential to save considerable health burden and costs. Adherence in mental health is no different. [read the full story…]
Seeing is believing; how does family presence during cardiopulmonary resuscitation affect psychological outcomes for family members?
There are around 60,000 out-of-hospital cardiac arrests in the UK every year. Some of these events occur in the presence of relatives who may witness the cardiopulmonary resuscitation (CPR) by the resuscitation team (you can find out more about CPR at the Resuscitation Council’s website). The emotional consequences of this for the relatives and the [read the full story…]
The CHAMP RCT finds that CBT is more effective than standard care for reducing health anxiety
Cognitive behavioural therapy (CBT) is substantially more effective than standard care at reducing symptoms of health anxiety in medical patients, and can be delivered by non-specialist staff with minimal training at little extra cost, according to an RCT published by The Lancet today. The CHAMP (Cognitive behaviour therapy for Health Anxiety in Medical Patients) trial [read the full story…]
Using adaptive treatments for smoking cessation may prove effective
Around 20% of adults in the UK smoke cigarettes regularly. Smoking was the primary cause of approximately 462,900 hospital admissions and 79,100 (18%) deaths in adults over the age of 35 last year. Therefore, smoking cessation represents a serious (and costly!) clinical challenge on an individual and global level. Many smoking cessation aids are available, [read the full story…]