Have the EAGLES landed? Safety of varenicline, bupropion and NRT in smokers with and without mental illnesses

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Paul Christiansen presents the results of the EAGLES RCT into the neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patches in smokers with and without psychiatric disorders.

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Internet-based problem-solving guided self-help for depression whilst waiting for therapy

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Alastair Canaway summarises a trial of the clinical and cost-effectiveness of internet-based problem-solving guided self-help intervention, in comparison with enhanced usual care, for outpatients on a waiting list for face-to-face treatment for major depression.

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ITI-007 for schizophrenia

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Murtada Alsaif summarises a recent 4-week long phase II randomised controlled trial of ITI-007 for the treatment of schizophrenia, which contains some positive results for this novel intervention.

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Parent-focused treatment for anorexia in adolescents: more efficient than family-based treatment says new RCT

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Dave Steele summarises a recent RCT which compares Parent-Focused Treatment and Family-Based Treatment for adolescents with Anorexia Nervosa.

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Telehealth for depression: large pragmatic RCT of complex intervention

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Emily Stapley presents the findings of a trial which looks at the effectiveness of an integrated telehealth service for patients with depression.

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Group body psychotherapy for negative symptoms of schizophrenia

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Raphael Underwood reports on the findings of a recent RCT of group body psychotherapy for negative symptoms of schizophrenia, which finds that body psychotherapy did not have a clinically beneficial effect on reducing emotional withdrawal or improving social functioning.

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Long-acting injectable paliperidone palmitate for schizophrenia

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Tracey Roberts summarises a recent RCT of the efficacy and safety of paliperidone palmitate 3-month formulation for patients with schizophrenia.

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Web-based guided self-help can prevent or delay major depression

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Ioana Cristea is impressed by a large German randomised controlled trial published yesterday in JAMA, which shows web-based guided self-help to be effective in preventing or delaying the onset of major depression.

This blog also features a podcast interview with the lead author of the research, Professor Pim Cuijpers.

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Mental health literacy: can it be taught to teenagers?

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Jasmin Wertz reports on a recent Canadian cluster RCT, which studies the impact of a mental health curriculum for high school students on knowledge and stigma.

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Collaborative care for depression: acceptable, effective and affordable

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Ben Hannigan writes his debut blog on the CADET cluster RCT, which investigates the clinical effectiveness and cost-effectiveness of collaborative care for depression in UK primary care.

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