Time to ACT for insomnia? New trial finds possible alternative to CBTi

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Nicholas Donnelly considers a recent Brazilian randomised controlled trial of Acceptance and Commitment Therapy versus Cognitive Behavioural Therapy for insomnia.

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Quetiapine may pip lithium to the post for augmentation in ‘treatment resistant depression’: results from the LQD study

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Kirsten Lawson and Douglas Badenoch review the new randomised controlled trial by Cleare et al, published today in The Lancet Psychiatry, directly comparing the clinical and cost effectiveness of lithium and quetiapine as augmentation treatments for patients with ‘treatment resistant depression’.

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Home-based brain stimulation (tDCS) for depression: ready for widespread use?

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Julian Mutz discusses the results of a new 10-week RCT assessing home-based brain stimulation for depression, which suggests that tDCS may be a safe, acceptable and efficacious treatment for moderate depression.

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Will this ADHD medication help my patient? Bridging the gap between efficacy and effectiveness

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Shuichi Suetani blogs a new study published today in The Lancet Psychiatry, which suggests that those patients who might benefit most from evidence-based guidance are the least represented in clinical trials about ADHD medication. Is it time to reconsider the value we place on RCTs when they do not include the vast majority of people who need help?

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Omega-3 supplements for the prevention of psychosis: another trial shows no benefit, so is it time to move on?

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David Mongan reports on a recent trial of omega-3 supplementation for the prevention of psychosis in people at ultra-high risk, which finds no evidence of a positive effect. He reflects on these findings and considers what’s next for the field.

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KarXT: an innovative and promising treatment for schizophrenia

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Nicola Rizzo Pesci and Andrea Cipriani summarise findings from the EMERGENT-2 trial spotlighting a promising new drug treatment for schizophrenia.

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ACT now for MND: acceptance and commitment therapy can improve quality of life for people with motor neuron disease

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Dona Matthews summarises a recent trial which suggests that Acceptance and Commitment Therapy can maintain or improve quality of life for people with early stage motor neuron disease.

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Can self help apps PROMOTE wellbeing or PREVENT illness in young adults?

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Kirsten Lawson summarises the ECoWeB PROMOTE and PREVENT trials in relation to self-helps apps for promoting wellbeing and preventing mental ill health among young adults.

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Apps for depression and anxiety: big new meta-analysis supports effectiveness

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In their debut blog, Lee Valentine summarises a large-scale updated meta-analysis investigating the effectiveness of mental health apps for depression and anxiety.

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Is my depression the same as your depression? Network analysis finds individual variation in how symptoms aggravate each other over time

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Giulia Piazza and Jonathan Roiser explore a recent network analysis and ecological momentary assessment study, which provides clear evidence that the relationships between depressive symptoms vary between individuals with depression who are matched on overall depression severity.

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