Cannabis use disorder associated with increased risk of both psychotic and nonpsychotic unipolar depression and bipolar disorder

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Jack Wilson critiques a recent Danish longitudinal study published in JAMA Psychiatry, which suggests that cannabis use disorder is independently associated with bipolar disorder and unipolar depression.

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Antidepressants for depression: new BAP guidance

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Helge Hasselmann summarises the recently published evidence-based guidance on antidepressants for depression published by the British Association for Psychopharmacology.

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New Cochrane review finds weak evidence that drug combinations are more effective than monotherapy in psychotic depression

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Major depression remains a serious condition that often proves refractory to pharmacological or psychotherapeutic interventions. Because depression can have many “faces”, clinicians should be aware of the great symptom variability among depressed patients and consider subforms when prescribing medication.  In a sizeable amount of patients (up to 25%, Coryell et al., 1984), depression presents with [read the full story…]

Do interventions proven to improve cardiovascular disease outcomes work for individuals with severe mental illness?

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Individuals with severe mental illness (SMI) have shortened life expectancies compared to the general population. This is partly down to higher rates of chronic physical illness. Cardiovascular disease (CVD) is the leading cause of death among patients using mental health services. It is assumed that interventions used to reduce CVD are similarly effective in patients with [read the full story…]