KarXT: an innovative and promising treatment for schizophrenia

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Nicola Rizzo Pesci and Andrea Cipriani summarise findings from the EMERGENT-2 trial spotlighting a promising new drug treatment for schizophrenia.

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Cognition and heterogeneity in first-episode psychosis before antipsychotic treatment

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Ana Veic looks at an updated systematic review which suggests that patients with psychosis display cognitive difficulties very early in the disease process, and concludes this variation in cognitive function should prompt individual clinical assessments to optimise care.

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Here comes the sun: associations between daily light exposure and psychiatric disorders

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Emiliana Tonini summarises a large-scale cross-sectional study, which suggests that encouraging individuals to increase their exposure to bright natural light during the day and minimise exposure to artificial light at night may help with our mental health.

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Just how good are antipsychotics at preventing relapse? Bridging the efficacy-effectiveness gap

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Samei Huda summarises a new network meta-analysis in the Lancet Psychiatry on the efficacy and effectiveness of antipsychotics for schizophrenia in research settings, such as randomised controlled trials, versus real-world and clinical settings.

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Lived experience perspectives of acceptance and commitment therapy for people with psychosis

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Charlotte Huggett reflects on a qualitative study exploring the perspectives of people with psychosis receiving Acceptance and Commitment Therapy following a first episode of psychosis.

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Compassion-focused therapy for psychosis: study suggests it’s feasible and acceptable, so what next?

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Ellen Iredale and Poppy Brown summarise a case-series study on compassion‐focused therapy for distressing hallucinations and delusions in psychosis, suggesting the potential to benefit people with psychosis.

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Early intervention for psychosis: better outcomes in the short term?

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Emanuele Osimo blogs about the 20-year follow up of the OPUS trial, which tested early intervention services for people with first-episode schizophrenia spectrum disorder.

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‘Hearing Voices’ and self-help groups: hope and support for people who hear voices

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Lorna Collins reflects on a systematic review exploring the benefits of Hearing Voices and other self-help groups for people with auditory hallucinations.

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Neuroimaging abnormalities in first-episode psychosis: clinically-relevant or not?

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Joe Pierre considers a systematic review and meta-analysis on the prevalence of neuroimaging abnormalities in first-episode psychosis and the clinical relevance for service users presenting with first-episode psychosis.

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