Off-label antidepressants: limited evidence to support their use

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John Baker reports on Canadian study looking at prescriptions of off-label antidepressants in primary care, which concludes that when antidepressants were used outside of their licence, there was usually not strong evidence supporting the respective indication.

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Depression in later life: who benefits most from antidepressants plus exercise?

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Linda Gask explores an RCT of physical exercise for depression in later life, which considers the best way to customise the intervention for primary care.

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Diet and depression: can we eat our way out of clinical depression? The ‘SMILES’ trial

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Murtada Alsaif chews over the SMILES RCT of dietary improvement for adults with major depression, which reports encouraging results for healthy diet in people with depression.

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Collaborative care may help older adults with subthreshold depression: CASPER trial

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Ben Hannigan summarises the new CASPER trial of collaborative care versus usual care for older adults with subthreshold depression.

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Annual health checks may reduce emergency hospital admissions for preventable conditions

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Pauline Heslop summarises a UK primary care study that shows how emergency hospital admissions for preventable conditions can be reduced in people with learning disabilities who receive annual health checks.

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Depression and coronary heart disease: reasons to remain UPBEAT-UK

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Kirsten Lawson summarises the UPBEAT-UK programme of research into the relationship between coronary heart disease and depression and anxiety in primary care patients.

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Training alone doesn’t improve outcomes for depression in primary care

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Linda Gask writes her debut Mental Elf blog on a recent systematic review, which evaluates healthcare team training programs that aim to improve depression in primary care.

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Treatment is uncommon for common mental disorders

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Suzanne Dash reviews a cross-sectional study of the prevalence and treatment of common mental disorders in the English national population, which inspires her to host a mental health epidemiology quiz. Fingers on buzzers…

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Telehealth for depression: large pragmatic RCT of complex intervention

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Emily Stapley presents the findings of a trial which looks at the effectiveness of an integrated telehealth service for patients with depression.

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Whooley questions have high sensitivity and modest specificity in the detection of depression

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Ian Anderson on a recent diagnostic accuracy meta-analysis, which shows that the Whooley questions for depression are effective at ruling out the condition, but that false positives are common.

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