11 RCTs were included in this review of statins as an adjunct to scaling and root planing. The findings suggest improvements in pocket depth and clinical attachment levels with statin use.
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10 randomised trials were included in this review of he adjunctive use of statins with scaling and root planing for treatment of chronic periodontitis . The findings suggest additional benefits with their use regardless of health or smoking status.
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12 observational studies were included in this review of the effect of khat chewing on periodontal tissues. The available evidence is of limited quality but it suggests that khat use has an adverse effect on periodontal status.
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This reviews of the efficacy of periodontal maintenance treatment carried out in primary care compared to the specialist setting following specialist treatment included 8 cohort studies. The quality of the available evidence was limited suggesting outcomes may be poorer in primary care further high quality studies are required
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This review of periodontal regeneration therapies included 52 trials. While the results suggest some statistically significant improvements they may not be clinically important. There is also limited data for outcomes longer than 12 months.
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4 small RCTs of probiotics as an adjunct to scaling and root planing for management of chronic periodontitis were identified for this review. While a statistical significant benefit was demonstrated the limited number of small studies means that these findings should be interpreted with caution.
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This review of salivary biomarkers for diagnosing periodontal disease only identified 4 studies at high risk of bias but suggests a small number of potential biomarkers. However the findings should be interpreted with caution.
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This review of probiotics use for caries and periodontal disease management identified 50 studies. Most focused on surrogate outcomes (bacterial counts) and the overall quality of the evidence supporting probiotic therapy was graded as very low for all outcomes.
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This review of the adjunctive use of amoxicillin and metronidazole with scaling and root planing for the management of periodontitis found improved clinical outcomes in terms of pocket depth and clinical attachment level with their use.
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This review of platelet-rich plasma for intrabony periodontal defects included 21 studies. These were mainly small studies with a marked degree of heterogeneity. They suggest some potential benefits but the findings should be interpreted with caution.
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