Gemma Lewis and Glyn Lewis summarise a robust systematic review and meta-analysis investigating the incidence of symptoms when discontinuing or withdrawing from antidepressants. The data suggest that 8-14% of patients will experience antidepressant discontinuation symptoms, and for around 2% these symptoms will be severe.
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This review estimating the nocebo response in dentistry from trials of analgesic treatment following third molar surgery included data from 50 RCTs. Adverse events (AEs) were roughly the same in placebo and active arms suggesting AEs may be attributed to the nocebo phenomenon.
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Angharad de Cates reviews a recent Danish trial, which finds that escitalopram reduced participants’ reinforcement sensitivity compared to those on placebo. This lower reinforcement sensitivity may be similar to the emotional blunting effect often reported by patients during SSRI treatment.
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Susannah Murphy summarises a new Cochrane review and network meta-analysis, which provides the best evidence to date about new generation antidepressants for depression in children and adolescents.
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This review the efficacy of stabilisation appliances in the management of painful temporomandibular disorders (TMDs) included 24 RCTs. The findings suggest they have an efficacy beyond the placebo effect however the evidence of low to very low certainty.
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This network meta-analysis of the efficacy of antifungal drugs on oral candidiasis included 31 RCTs of overal low quality suggesting that fluconazole may be the most effective.
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This review of the effects of different types of lasers on dentine hypersensitivity included 11 RCTs suggesting no significant differences between Er,Cr:YSGG, Nd:YAG, Er:YAG, and GaAlAs lasers both in the immediate term and at 1 month.
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This network meta-analysis comparing the effect of different desensitising toothpastes on dentine hypersensitivity included 30 RCTs. The findings suggest that toothpastes containing nano-hydroxyapatite or arginine may be the most effective. However additional larger studies are required.
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Inês Pote summarises a recent meta-analysis of randomised placebo-controlled trials of cognitive behavioural therapy for anxiety and related disorders.
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This network meta-analysis of oral premedication to improve anaesthetic success of inferior alveolar nerve block in patients with irreversible pulpitis suggest that that oral premedication with dexamethasone, NSAIDs and Tramadol increases the success rate.
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