Is my depression the same as your depression? Network analysis finds individual variation in how symptoms aggravate each other over time

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Giulia Piazza and Jonathan Roiser explore a recent network analysis and ecological momentary assessment study, which provides clear evidence that the relationships between depressive symptoms vary between individuals with depression who are matched on overall depression severity.

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Psychotherapy experiences of young people in foster care: suggestions for practice

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In her debut blog, Charlotte Kitchen reviews a small qualitative study from Ireland, which explores how young people in foster care feel about psychotherapy.

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Personalised medicine: a transformative era in dementia research

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Nagina Khan writes her debut elf blog on a recent study in the British Journal of Psychiatry about the individual course of neuropsychiatric symptoms in people with Alzheimer’s and Lewy body dementia.

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Can a ‘personalised psychosocial toolbox’ help people reduce ‘on-top’ drug use during opioid substitution treatment?

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Vicky Carlisle summarises a promising recent RCT on the efficacy and cost-effectiveness of an adjunctive personalised psychosocial intervention in treatment-resistant maintenance opioid agonist therapy.

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Genetics of depression: understanding risk and improving treatment

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Douglas Levinson on a genome-wide meta-analysis of depression in 807,553 individuals, which identifies 102 independent variants relating to the genetics of depression.

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Improving antidepressant outcomes: what works for whom and why?

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Thalia Eley and Gerome Breen explore a new systematic meta-review of predictors of antidepressant treatment outcome in depression, which looks at clinical and demographic variables, but also biomarkers including both genetic and neuroimaging data.

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The Lancet Psychiatry Commission on psychological treatments #SeeingFurther

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Ioana Cristea highlights some of the key ideas from the recently published Lancet Psychiatry Commission on psychological treatments research in tomorrow’s science. She also raises a number of objections to the 50-page report, which we hope will generate some much needed discussion on this topic.

Look out for our #SeeingFurther podcast with the authors of the Commission and a Twitter chat at 12:30pm GMT on Monday 19th March.

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Innovation case studies point to a co-productive approach acknowledging risk taking and organisational development

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Alison Turner summarises a new digital report from the King’s Fund, which features a range of case studies highlighting how innovations have improved patient care and experience.

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How should we personalise treatment for adults with depression?

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One of the criticisms that health professionals sometimes make of evidence-based research is that individual studies or reviews do not apply to the specific patient they are caring for. Of course, each patient is unique with their own values and preferences, as well as their own particular clinical characteristics, genetic make-up, biological markers and sociodemographic [read the full story…]