This review of whether metronidazole used as monotherapy or in addition to a β-lactam antibiotic offers any additional benefit over β-lactam monotherapy in non- periodontal dental infections includes 3 RCTs. The findings suggest that metronidazole does not provide superior clinical results compared to β-lactam antibiotics for the treatment of non-periodontal dental infections. However the evidence is limited and of low quality.
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This review of the efficacy of of analgesics on the relief of pain during orthodontic treatment included 12 RCTs. The findings demonstrate that analgesics were more effective than placebo in controlling orthodontic pain
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Colin Levey takes a look at this network meta-analysis of 46 RCTs assessing techniques and drugs for achieving pulpal anaesthesia for the non-surgical endodontic treatment of mandibular molars.
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This review of different methods for reducing pain and discomfort during removal of fixed orthodontic appliances included 6 RCTs providing weak evidence for pre-debonding analgesia and other approaches.
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This Cochrane review of drug interventions for pain during orthodontic treatment including 32 RCTs find that analgesics were effective in reducing pain. However, low quality evidence did not show a difference in effectiveness between systemic NSAIDs compared with paracetamol, or topical NSAIDs compared with local anaesthetic.
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16 RCTs involving 1900 patients were included in this review of pre-op analgesia for patients with pulpitis . The findings suggest that premedication with analgesics improves the success rate of local anaesthesia.
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The review of NSAIDs for endodontic postoperative pain suggests that NSAIDs are effective. A combination of ibuprofen 600 mg and acetaminophen 1000 mg and Ibuprofen 600 mg were both effective. More studies are need to assess teh most effective NSAIDs dosages and does intervals.
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This Cochrane review found 5 RCTs of pre-op analgesics prior to dental treatment for children under local anaesthetic. The evidence as insufficient to determine a benefit but there may be a benefit prior to orthodontic band placement. Further high quality studies are needed.
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This is the latest update of this Cochrane review of the effectiveness of antibiotics for irreversible pulpitis. Only 1 small RCTs is available which provides insufficient evidence to determine whether antibiotics reduce pain or not compared to not having antibiotics
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This overview includes 39 Cochrane reviews with data from around 460 studies and about 50,000 patients providing a wealth of reliable evidence on the analgesic efficacy of single dose oral analgesics.
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