This review of different topical medications for the management of recurrent aphthous stomatitis (RAS) included 43 RCTs. No significant differences were found for any if the treatments assessed and a majority of the included RCTs (76%) were considered to be at high risk of bias.
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Our most read blogd in October, November and December 2022 covered treatments for burning mouth syndrome, recurrent oral aphthous stomatitis and preformed metal crowns on primary molars
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This review of the efficacy and safety of topical interventions used for recurrent aphthous stomatitis included 72 studies assessing 29 different interventions. Most of the interventions did not demonstrate significant differences with limitednumbers of studies for some interventions and overal limitations in the quality of the evidence.
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This review of the evidence on possible association between locally delivered nicotine replacement therapy(NRT) and oral side effects included 28 RCTs. Most of the RCTs were at high risk of bias mainly because of allocation concealment concerns. Reported oral side effects including oral soreness, gastric reflux or vomiting, and mouth or throat irritation.
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This review of the efficacy of vitamin B in treating mouth ulcers included 16 RCTs published since 2010. All the included studies were published in Chinese with the findings that treatment was more effective in patients treated with vitamin B.
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This review of the potential association between zinc levels and occurrence of Recurrent aphthous stomatitis (RAS) included 19 case-controlled studies. The findings show a sigificant association between low zinc levels and RAS.
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Marianne Dobson takes a look at this systematic review of the orofacial manifestations of systemic lupus erythematosus (SLE). The review included 30 studies and provides a narrative summary of a issues related to orofacial symptoms and management. However good quality prospective studies are needed to improve the the quality of evidence surrounding this topic.
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This review of a possible association between vitamin D deficiency and recurrent aphthous stomatitis (RAS) included 5 case control studies providing limited evidence that low levels of serum vitamin D might be a risk factor for RAS.
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This review of the effects of sodium lauryl sulphate (SLS) free and SLS-containing toothpastes in patients with recurrent aphthous stomatitis (RAS) included 4 small RCTs with the findings suggesting that patients with RAS may benefit from using SLS-free toothpaste. However the quality of teh availabel studies is very low.
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This review focuses on the treatment of oral ulceration in Behçet’s disease, 15 trials examining 13 different interventions were found. There was insufficient evidence to support or refute the use of any included intervention with regard to pain, episode duration, or episode frequency associated with oral ulcers, or safety of the interventions.
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