Manas Dave looks at a review of the diagnostic accuracy of blood and salivary microRNAs (miRNAs) in discriminating oral squamous cell carcinoma. The review included 20 cross-sectional studies and suggested moderate diagnostic accuracy and higlights a potential are for larger scale studies.
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This review of the potential association between zinc levels and occurrence of Recurrent aphthous stomatitis (RAS) included 19 case-controlled studies. The findings show a sigificant association between low zinc levels and RAS.
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This review of the links between the habit of betel quid and areca nut (BQ-AN) chewing and the prognosis of oral cancer included 11 observational studies. The findings suggest that lower 5-year survival is seen in those with a BQ-AN chewing habit.
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In this blog Rajpal Tattar looks at a review and meta-analysis investigating the correlation between oral lichen planus and peri-implant disease. Only two small observational studies were included so the availabel evidence is very limited.
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In this blog Manàs Dave looks at a systematic review of treatment options for patients with Burning Mouth Syndrome (BMS). Study heterogeneity means that only a narrative summary was possible so there is a need for high quality research in this area.
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This review looked at the efficacy of photodynamic therapy (PDT) for the treatment or oral lichen lplanus (OLP) and compares PDT with steroid therapy. 16 studies were included with the findings suggesting that photodynamic therapy may offer patients with OLP improved pain relief and better efficacy compared to topical corticosteroids.
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Manas Dave considers this review of the safety and reliability of digital pathology. The review included 24 studies showing high concordance between digital pathology and light microscopy suggesting that digital pathology is a viable alternative to light microscopy.
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In his first blog for the Dental Elf Rajpal Tattar take a look at a review of the diagnostic accuracy of salivary biomarkers for the detection of oral squamous cell carcinoma (OSCC). The review considers two biomarkers, cytokeratin 19 fragment (CYFRA 21-1) and for matrix metalloproteinase-9 (MMP-9) but there is no conclusive evidence for either at present.
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This review of metastasis to the oral and maxillofacial region included 217 studies (190 case reports,24 case series ). Metastasis were uncommon, but identified from 29 primary sites, the most common sites being lung the lungs (20.97%), breast (12.06%) and kidney (11.78%).
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Manas Dave looks at a recent review of which considers the efficacy of optical fluorescence imaging as an adjunct to clinical oral examination for the detection of oral mucosal lesions. The review includes 27 studies and provides evidence to support additional high quality studies to assess its effectiveness.
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