This review was first published in 2009 . The American Dental Association Centre for Evidence-based Dentistry has now published a critical summary of this review. The original review included 12 clinical trials involving 1818 patients and concluded that a twice-daily regimen of Chlorhexidine gel (0.2 percent) applied every 12 hours for seven consecutive days can [read the full story…]
Non-steroidal anti-inflammatory drugs (NSAIDs) use has been associated with a reduced risk of a number of cancers. The mechanism is thought to be via the inhibitory action on the cyclooxygenase (COX) enzyme, COX-2. The aim of this review was to investigate the association between NSAID/aspirin use and risk of head and neck cancer (HNC). The [read the full story…]
This cohort study of 327 oral lichen planus (OLP) patients; 229 women (70.0%) and 98 men (30.0%), was conducted using data from a cohort of caucasian patients from Italy with clinical and pathologic diagnosis of OLP, according to revised and modified World Health Organization diagnostic criteria. Follow-up of the patient cohort was started 6 months [read the full story…]
The aims of the study were to determine how frequently oral potentially malignant disorders (OPMDs) transform to cancer and to identify clinical and histological factors determining the rates of transformation. The study cohort included 1357 patients with biopsy-confirmed OPMDs seen at Guy’s Hospital between 1990 and 1999 and followed up until 2005. The patients’ details [read the full story…]
The aim of this Cochrane review was to assess the effectiveness and safety of interventions to treat symptomatic, biopsy-proven oral lichen planus (OLP). OLP is a common chronic autoimmune disease associated with cell-mediated immunological dysfunction. The prevalence has been reported as 1.27% and it is more frequently seen in women aged between 30 and 60 [read the full story…]
Patients taking bisphosphonates are at increased risk of oral health complications (Bisphosphonate-related Osteonecrosis of the Jaw – BONJ). BONJ is defined as exposed, necrotic bone in the maxilla or mandible that has persisted for more than eight weeks in patients taking bisphosphonates and where there has been no history of radiation therapy to the jaw. Symptoms [read the full story…]
