This Cochrane review update was to estimate the diagnostic accuracy of index tests for the detection of oral cancer and oral potentially malignant disorders, in people presenting with clinically evident suspicious and innocuous lesions.
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This diagnostic review compared two computer aided adjunctive tests for oral cancer. Oral CDX and DNA-image cytometry. The results suggest that DNA-image cytometry has a highly significant potential over OralCDx brush biopsy as an accurate and simple diagnostic tool for clinically suspected oral precancer and oral cancer.
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This Cochrane review of adjunctive diagnostic tests for oral cancer included 41 studies assessing vital staining, cytology, and light-based tests. The available studies were of poor quality detection with none of the tests being considered as a replacement for the currently used standard of a scalpel biopsy and histological assessment.
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