This Cochrane review of bisphosphonate related osteonecrosis of the jaw only identified one small RCT. The trial compared the use of hyperbaric oxygen (HBO) as an adjunct to standard care. While it suggested a benefit for HBO it was under powered and at high riisk of bias
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65 case reports and 1 case series were included in this reviews of the ophthalmic side effects from dental local anaesthesia. 92 % were transitory the remainder permanent. 25% of the transitory side effects took up to 6 hours to resolve.
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12 trials were included in this Cochrane review of molecularly targeted therapies and immunotherapies as adjuncts to standard treatments for oral cancer. Moderate evidence was found that standard therapy plus epidermal growth factor receptor monoclonal antibody (EGFR mAb) reduced mortality and locoregional failures.
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The worldwide prevalence of third molar impaction estimated from this review including 49 studies involving 83,484 individuals was 24.4% (95% CI;18.97% to 30.80%).
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This review of piezoelectric surgery for third molar removal included 9 studies, 6 of which were RCTs. The findings suggest that outcomes were better for piezoelectric surgery but these findings should be viewed cautiously.
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This review included 8 RCTs involving a total of 476 patients and found that submucosal dexamethasone reduced postoperative pain and swelling. Although only one of the studies was at low risk of bias and there was a possibility of publication bias, the findings should be considered with caution.
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Thirteen studies were included in this review of medication related osteonecrosis of the jaw. The majority were case series ( 9) with the risk of osteonecrosis after tooth extraction being higher in those taking IV bisphosphonates ( 3.2% (95% CI: 1.7–4.7%) than those on oral bisphosphonates 0.15% (95% CI: 0.0–0.36%).
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While there are a number of reviews of treatment options for the keratocystic odontogenic tumour (KCOT), this update of a Cochrane review could identify no relevant RCTs of treatment options. So there is a clear need for well designed and conducted randomised controlled trials to evaluate treatments for KCOTs.
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5 studies were included in this review of hilotherapy. While the studies suggest that hilotherapy might provide patients with a significant reduction in postoperative facial pain and oedema, the quality of the studies is low.
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This overview includes 39 Cochrane reviews with data from around 460 studies and about 50,000 patients providing a wealth of reliable evidence on the analgesic efficacy of single dose oral analgesics.
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