This review of the evidence on possible association between locally delivered nicotine replacement therapy(NRT) and oral side effects included 28 RCTs. Most of the RCTs were at high risk of bias mainly because of allocation concealment concerns. Reported oral side effects including oral soreness, gastric reflux or vomiting, and mouth or throat irritation.
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Andrew Jones reports on a recent systematic review and network meta-analysis of the efficacy and tolerability of pharmacotherapy for smoking cessation in severe mental illness, which finds a promising but low quality result for bupropion and varenicline.
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In addition to being a risk factor for mouth cancer and periodontal disease, smoking is associated with staining of the teeth. Nicotine replacement therapy (NRT) is widely used to assist patients quit smoking. In vitro tests of NRT gum have suggested that they may have stain reduction effects. A product which not only assists smokers [read the full story…]
