Antidepressants, cognition, and emotional blunting: what’s the evidence?

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Angharad de Cates reviews a recent Danish trial, which finds that escitalopram reduced participants’ reinforcement sensitivity compared to those on placebo. This lower reinforcement sensitivity may be similar to the emotional blunting effect often reported by patients during SSRI treatment.

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Can ketamine metabolites and gamma power help predict clinical response for ‘treatment resistant depression’?

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Anya Borissova summarises a recent randomised placebo-controlled trial that evaluated ketamine metabolites, clinical response, and gamma power for major depression.

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