Kirsten Lawson and Douglas Badenoch review the new randomised controlled trial by Cleare et al, published today in The Lancet Psychiatry, directly comparing the clinical and cost effectiveness of lithium and quetiapine as augmentation treatments for patients with ‘treatment resistant depression’.
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Michael Kalfas and Paul Leeks summarise a recent Danish study that assesses the risk of antidepressant-induced mania in patients with bipolar depression.
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Deenan Edward and Suhana Ahmed summarise a Scottish study of prescribing for bipolar disorder between 2009-2016, which identified a clear trend towards decreasing lithium use.
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Leela Sathyaputri and Jess Fiedorowicz write their debut elf blog on a narrative review of the recent bipolar disorder literature entitled: “Areas of uncertainties and unmet needs in bipolar disorders: clinical and research perspectives”.
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Dean Connolly looks at an international study which asks: Is there consensus across evidence-based guidelines for the psychotropic drug management of bipolar disorder during the perinatal period?
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Keir Harding prepares for the #BIGSPD19 conference by reading Mike Crawford et al’s recent RCT on the clinical effectiveness and cost-effectiveness of lamotrigine in borderline personality disorder.
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Kathryn Mitchell and Stephen Moore summarise a recent prospective cohort study in the British Journal of Psychiatry, which looks at the incidence of unipolar and bipolar depression, and mania in adults with intellectual disabilities.
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Murtada Alsaif considers a recent systematic review on the safety and efficacy of adjunctive second-generation antidepressant therapy with a mood stabiliser or an atypical antipsychotic in acute bipolar depression.
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Joseph Hayes summarises the recent British Association for Psychopharmacology guidelines for the treatment of bipolar disorder, and compares their recommendations with those found in the NICE bipolar disorder guidance from 2014.
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Joanne Wallace considers a recent health technology assessment on the risks and benefits of psychotropic medication in pregnancy, which supports previous associations between valproate and adverse child outcomes.
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