Cellular immune phenotypes of depression: a gateway to precision medicine 

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In her debut blog, Fabiana Corsi-Zuelli summarises a recent systematic review and meta-analysis investigating the role of peripheral immune cells in depression, with a focus on implications for future immunotherapy trials.

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Serotonin hypothesis of depression: balance (and imbalance) is in the eye of the beholder

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The 2022 review by Moncrieff et al on the serotonin theory of depression received a great deal of media coverage. In this blog, Rebecca Wilkinson and Sameer Jauhar shed fresh light on this research and what it means for mental health science and practice.

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Beyond thought and behaviour: is psychosis more than a brain disorder? 

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Shuichi Suetani writes his debut elf blog on a new meta-review that asks: Is psychosis a multisystem disorder? This blog explores central nervous system, immune, cardiometabolic, and endocrine alterations in first-episode psychosis and perspective on potential models.

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Tetris for PTSD: behavioural intervention unlikely to vaccinate against intrusions

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Ioana Cristea disputes the claims of a recent proof-of-concept RCT, which aims to prevent intrusive memories after trauma via a brief intervention involving Tetris computer game play in the emergency department.

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