Maintenance or discontinuation of antidepressants for depression? Findings from the ANTLER trial

For every 6 people stopping their medication there was one additional relapse compared to those who maintained their antidepressant treatment, suggesting that stopping medication has an increased risk of relapse.

Raphael Rifkin-Zybutz and Sameer Jauhar summarise the recently published ANTLER trial, which explores whether antidepressant maintenance can reduce the risk of relapse in depression.

[read the full story...]

In adults with major depression, antidepressants may increase the risk of suicide

shutterstock_409500925

Douglas Badenoch explores a meta-analysis of follow-up data from clinical trials of antidepressants, which found a small but significant increase in suicide risk.

[read the full story...]

Time to stop prescribing antidepressants to young people with depression?

photo-1456397807017-5a6b47d257f4

Andrew Shepherd considers the implications of a recent network meta-analysis of the efficacy and tolerability of antidepressants for children and adolescents with depression.

[read the full story...]

Can a machine learning approach help us predict what specific treatments work best for individuals with depression?

9990016123_b58fa297eb_h

Marcus Munafo explores a recent study that uses a machine learning approach across two trials (STARD*D and CO-MED) to try and predict treatment outcomes (primarily focusing on the antidepressant citalopram) for depression.

[read the full story...]