This review of different surgical treatments for odontogenic keratocsysts (OKC) with respect to recurrence rates includes 40 observational studies. The finding suggest that enucleation plus peripheral ostectomy/curettage and 5-Fluorouracil had the lowest recurrence rate and enucleation alone the highest but the evidence is mainly of very low certainty.
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This review of factors influencing eruption of teeth associated with dentigerous cysts only included 4 small single-centre retrospective studies providing very low certainty evidence.
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29 mainly retrospective studies were included in this review of conservative management approaches for odontogenic keratocysts. While the findings suggest use of decompression followed by enucleation data for recurrence were lower than those found in previous reviews of the topic. High quality prospective studies are needed.
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This review of surgical approaches for keratocystic odontogenic tumour identified 35 mainly retrospective studies. Radical resection had the lowest recurrence rate but has significant morbidity. Higher quality evidence is to clarify the evidence for the varying surgical approaches.
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This review of the management of keratocystic odontogenic tumors included 14 mainly retrospective studies ans suggests that initial cystectomy, with or without adjuvant therapy, is associated with the least chance of recurrence.
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While there are a number of reviews of treatment options for the keratocystic odontogenic tumour (KCOT), this update of a Cochrane review could identify no relevant RCTs of treatment options. So there is a clear need for well designed and conducted randomised controlled trials to evaluate treatments for KCOTs.
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