Cognition and heterogeneity in first-episode psychosis before antipsychotic treatment

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Ana Veic looks at an updated systematic review which suggests that patients with psychosis display cognitive difficulties very early in the disease process, and concludes this variation in cognitive function should prompt individual clinical assessments to optimise care.

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Cannabis use disorder associated with increased risk of both psychotic and nonpsychotic unipolar depression and bipolar disorder

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Jack Wilson critiques a recent Danish longitudinal study published in JAMA Psychiatry, which suggests that cannabis use disorder is independently associated with bipolar disorder and unipolar depression.

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Keep on movin’… Even small doses of physical activity can lower our risk of depression

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Elli Kypraiou considers a systematic review published in JAMA Psychiatry, which suggests that relatively small doses of physical activity were associated with substantially lower risks of depression.

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Brain-body health please: new research supports integrated physical and mental health care

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Athina Aruldass finds that management of serious neuropsychiatric disorders should acknowledge the importance of poor physical health and target restoration of both brain and body function.

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Early intervention for psychosis: better outcomes in the short term?

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Emanuele Osimo blogs about the 20-year follow up of the OPUS trial, which tested early intervention services for people with first-episode schizophrenia spectrum disorder.

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Neuroimaging abnormalities in first-episode psychosis: clinically-relevant or not?

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Joe Pierre considers a systematic review and meta-analysis on the prevalence of neuroimaging abnormalities in first-episode psychosis and the clinical relevance for service users presenting with first-episode psychosis.

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The pill and ‘baby blues’: does experiencing depression with hormonal contraception predict postpartum depression?

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Flo Martin explores a recent cohort study of Danish registry data that investigate whether women with a history of depression associated with using hormonal contraception were also at a higher risk of developing postpartum depression.

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Brief interpersonal therapy may help relieve maternal depression during pregnancy

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In this blog, Francesca Kingston summaries a clinical trial from the US Care Project, which investigated whether depression can be reduced during pregnancy and before birth using a brief, safe intervention.

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Gut microbiome disruptions in depression: shifting the focus to metabolic signatures in blood

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Gerard Clarke explores a recent study which looks into the interplay of metabolome and gut microbiome in individuals with major depressive disorder.

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Everyday discrimination during the COVID-19 pandemic: the toll on mental health

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A group of UCL MSc students summarise a US study on the association of everyday discrimination with depression and suicidal ideation during the pandemic.

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