The role of the gut microbiome in treatment-resistant schizophrenia

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Nuala Murray explores a recent Australian case-control study that looks at the associations between changes in gut microbiota and schizophrenia diagnosis, treatment resistance, and clozapine response.

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The many faces of mental disorders

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Yuri Milaneschi discusses new research on the structure and presentation of mental health disorders, which suggests that although there are many different faces of major mental disorders, some of these faces are far more common than others.

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Is short sleep linked to risk of psychosis and could inflammation be a factor?

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Amy Ferguson summarises a recent study published by researchers in Birmingham, which suggests that persistent shorter sleep in childhood may increase the risk of psychotic experiences.

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Cognition and heterogeneity in first-episode psychosis before antipsychotic treatment

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Ana Veic looks at an updated systematic review which suggests that patients with psychosis display cognitive difficulties very early in the disease process, and concludes this variation in cognitive function should prompt individual clinical assessments to optimise care.

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Cannabis use disorder associated with increased risk of both psychotic and nonpsychotic unipolar depression and bipolar disorder

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Jack Wilson critiques a recent Danish longitudinal study published in JAMA Psychiatry, which suggests that cannabis use disorder is independently associated with bipolar disorder and unipolar depression.

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Keep on movin’… Even small doses of physical activity can lower our risk of depression

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Elli Kypraiou considers a systematic review published in JAMA Psychiatry, which suggests that relatively small doses of physical activity were associated with substantially lower risks of depression.

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Brain-body health please: new research supports integrated physical and mental health care

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Athina Aruldass finds that management of serious neuropsychiatric disorders should acknowledge the importance of poor physical health and target restoration of both brain and body function.

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Early intervention for psychosis: better outcomes in the short term?

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Emanuele Osimo blogs about the 20-year follow up of the OPUS trial, which tested early intervention services for people with first-episode schizophrenia spectrum disorder.

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Neuroimaging abnormalities in first-episode psychosis: clinically-relevant or not?

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Joe Pierre considers a systematic review and meta-analysis on the prevalence of neuroimaging abnormalities in first-episode psychosis and the clinical relevance for service users presenting with first-episode psychosis.

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The pill and ‘baby blues’: does experiencing depression with hormonal contraception predict postpartum depression?

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Flo Martin explores a recent cohort study of Danish registry data that investigate whether women with a history of depression associated with using hormonal contraception were also at a higher risk of developing postpartum depression.

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