Thalia Eley and Gerome Breen explore a new systematic meta-review of predictors of antidepressant treatment outcome in depression, which looks at clinical and demographic variables, but also biomarkers including both genetic and neuroimaging data.
[read the full story...]What can genetics tell us about the link between cannabis and schizophrenia? #MHQT
Suzi Gage summarises a recent GWAS of lifetime cannabis use, which reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Interesting new evidence ahead of our Mental Health Question Time #MHQT event in London tomorrow.
[read the full story...]Depression and anxiety: two sides of the same coin? #TransDX2018
Ava Schulz reviews a paper by Mansell and McEvoy which looks at psychopathology in a heterogenous clinical sample of anxiety and depression.
[read the full story...]The genetics of depression (and anxiety!)
Thalia Eley shares her thoughts on a recent Nature genome-wide association study of depression phenotypes in the UK Biobank, which uses different definitions of depression to provide more tractable targets for future genetic studies.
[read the full story...]Understanding the genetics of antipsychotic treatment response
Marcus Munafo looks at a Chinese genome-wide association study that claims to have identified some of the genes associated with response to antipsychotic treatment.
[read the full story...]Risk factors and peripheral biomarkers for schizophrenia spectrum disorders
Marcus Munafo considers the findings of a systematic review of meta-analyses of observational studies, which looks at risk factors and peripheral biomarkers for psychotic disorders on the schizophrenia spectrum.
[read the full story...]Autoimmune and autoinflammatory diseases associated with higher risk of eating disorders
Francesca Solmi appraises and summaries a recent population-based cohort study that explores the links between eating disorders and autoimmune and autoinflammatory diseases.
[read the full story...]Psychiatric genomics: an update and an agenda
Marcus Munafo comments on a review of the work of the Psychiatric Genomics Consortium, which in recent years has delivered an increasing flow of new knowledge about the fundamental basis of common psychiatric disorders.
[read the full story...]Genetics of depression: risk factors and protective factors
Marcus Munafò reports on a new genome-wide association study that identifies 44 risk variants and helps us to further refine the genetic architecture of major depressive disorder.
[read the full story...]Genetic correlations reveal new clues to anorexia nervosa
Marcus Munafo explores a new genome-wide association study of anorexia nervosa, which reveals significant locus and metabolic genetic correlations.
[read the full story...]