This review of the malignant development rate of oral erythroplakia and associated risk factors included 10 studies involving a total of 441 patients. Meta-analysis of 3 studies suggest a malignant development rate = 19.9% (95%CI; -1.6% to 41.4%).
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This review of the diagnostic accuracy of visual inspection compared with biopsy (gold standard) for the diagnosis or oral cancer and oral potentially malignant dissorders included 18 studies. For malignant lesions the pooled sensitivity was 88% (95%CI; 73% to 95%) and specificity 81%(95%CI; 51% to 95%).
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In this blog Manás Dave looks at a review of the prevalence of human papilloma virus (HPV) in oral potentially malignant disorders (OPMD). Although 52 studies were included one in five OPMDs being HPV positive is not a substantial link so teh findings need to be interpreted cautiously.
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This review of the prevalence of oral potentially malignant disorders included 22 observational studies providing a pooled estimate for prevalence of 4.47% (95% CI;2.43-7.08).
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14 studies were included in this review of the impact of oral potentially malignant disorders of the quality of life. However, they were mainly focused on oral lichen planus, so they provide little evidence for the impact of the wide range of OPMDs on the quality of life.
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This review of photodynamic therapy (PDT) for oral premalignant lesions only identified a small number of poor quality studies that provide insufficient evidence for the effectiveness of PDT for the management of oral premalignant lesions.
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