CBT may prevent depression in at-risk children whose parents have a history of depression

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The harmful impact of depression extends far beyond the individual sufferer to caregivers, friends and family members.  Children of people with depression are more likely to suffer from depression themselves.  This may be due to both inherited and environmental factors. This new randomised controlled trial (RCT), published earlier this week in JAMA Psychiatry, set out [read the full story…]

Psychiatric comorbidity increases the risk of premature mortality in epilepsy

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There is a back to school feeling in the air in the Woodland this week, and so this comes to you with the help of my shiny new yellow pencil case. Epilepsy affects around 70 million people around the world and premature mortality is substantial with almost half of epilepsy-related deaths occuring in those younger [read the full story…]

All scales are not equal; which is the best for detecting depression after stroke?

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Roughly 33% of stroke sufferers also develop depression at some point. This may be an under-estimate of the problem, as depression is difficult to detect in people with poor physical health. If missed, depression can led to reduced quality of life, increased disability and a worsening of physical symptoms. There are a whole host of [read the full story…]

Systematic review reveals conflicting evidence for relationship between diet and depression

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The question of what role nutrition plays in mental health has been the sauce (ahem) of research interest in recent times. As covered previously by oursElves in relation to dementia, the majority of this research has looked at individual nutrients like Omega-3 fish oil and other minerals, with the broader area of diet receiving less [read the full story…]

It’s not the combat, maybe it’s the drinking in vulnerable young men

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A cohort study published in JAMA tried to answer the question what are the risk factors for suicide in the US military. This is a hot topic as the rate of suicide has increased in US military personnel from about 11/100,000 people in 2005 to about 18/100,000 so that now deaths from suicide outnumber deaths [read the full story…]

Moderators of outcome in late-life depression: should we be prescribing antidepressants to older people?

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Meta-analyses are an incredibly useful tool for synthesising evidence. However, such analyses typically use aggregate data, meaning the average scores or outcomes for treatment groups, which can cause problems if we’re trying to dig a little deeper into the question of ‘what works’ to answer ‘what works, and for whom?’ The ‘for whom?’ question is [read the full story…]

Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: what about the impact of gender?

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Life after cancer diagnosis and treatment is full of uncertainties for the patients and their caregivers. The possibility of cancer returning is hard to dismiss at least in the first few years after the end of treatment. Life has often changed in many imperceptible and subtle ways for people who have undergone cancer treatment, as [read the full story…]

Can brain imaging help predict who will respond to CBT versus antidepressants?

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A major challenge in the treatment of depression is that only a proportion of people respond to the first treatment they try.  For example, with antidepressants only 40% of people will see their symptoms fall to a level that can be considered a recovery.  Trying further treatments after the first one does not work can [read the full story…]

More evidence needed on additional interventions to reduce mortality in older people with depression

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It has consistently been shown that a link exists between older adults who have depression and mortality (Cuijpers & Smit, 2002, Schulz et al., 2002). RCTs have demonstrated that treating depression during later life in primary care settings can result in the remission of depression and its associated symptoms as well as improve quality of [read the full story…]

Lack of evidence to support QOF incentives for assessing depression severity using tools in primary care

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Introduction The quality and outcomes framework was set up in 2004 to incentivise aspects of clinical practice within general practice in the UK. Two standards which are incentivised in depression are DEP4 (the percentage of patients who have had assessment of severity at diagnosis using a tool validated for use in primary care (PHQ-9, BDI-II, [read the full story…]