Placebo for depression: are some sugar pills better than others?

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Joe Judge revels in a new network meta-analysis looking at placebo for depression published in BMC Medicine, which has been supplemented by a series of commentaries and blogs. Thought-provoking stuff!

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Interpersonal therapy and imipramine may be effective at reducing suicidal ideation in depression, but more research needed

Susie Johnson considers how effective conventional depression treatments are at reducing suicidal ideation in depression. The new study she summarises concludes that interpersonal therapy and antidepressants can also reduce suicidal ideation.

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Face-to-face psychotherapy for chronic pain in children and adolescents: Cochrane review calls for better primary research

Lisa Burscheidt summarises a recent Cochrane review of psychotherapy for chronic pain in children and adolescents, which concludes that psychological therapies should be considered as a treatment, but better primary studies are needed to help steer pain management decisions.

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Mental disorders after critical illness: depression, PTSD and functional disability in survivors of intensive care

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The BRAIN-ICU prospective cohort study published in the Lancet Respiratory Medicine looks at mental health outcomes and functional disabilities in a general ICU population. It explores the hypothesis that depressive symptoms after discharge are more often somatic (i.e. bodily complaints) than cognitive-affective (i.e. thought-related and mood-related complaints).

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Combining psychotherapy and antidepressants is best for common mental illnesses

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Patrick Kennedy-Williams summarises a recent meta-analysis, which finds that combined treatment with psychotherapy and antidepressants is more effective than treatment with antidepressants alone.

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Interpersonal counselling for depression: RCT shows some promise

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Mark Smith summarises an RCT which compares SSRI antidepressants with interpersonal counselling for depression. The trial explores moderators of remission with interpersonal counselling or drug treatment in primary care patients with mild-moderate depression.

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Meta-review presents the risks of all-cause and suicide mortality in mental disorders

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This recent and well-conducted meta-review concludes that the impact on mortality and suicide of mental disorders is substantial, and probably poorly appreciated as a public health problem. Raphael Underwood’s blog summarises the data for all-cause and suicide mortality in mental disorders.

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Psychotherapy for depression in older adults: promising results, but insufficient good quality research

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This recent meta-analysis confirms that psychotherapy has a moderate to high effect on depression in older adults. However, a note of caution is sounded because of publication bias and the low quality of several of the included studies.

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Antidepressants, safety warnings and suicide risk in young people

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Andrew Shepherd reviews the recent controversial BMJ study that suggests the FDA black box warning about antidepressant use in young people, may have inadvertently caused an increase in suicidal behaviour. He finds it’s not quite that clear cut.

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Mindfulness-based cognitive therapy may reduce the demand for primary care visits

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Can’t get an appointment with your GP? Don’t stress, mindfulness-based cognitive therapy may help by reducing the demand for primary care visits by distressed patients, according to a new study in the Journal of Psychosomatic Research.

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