Are psychotic symptoms predictive of suicide attempts?

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Over the past several years, there has been a lively academic debate about what it means to have psychotic symptoms. Although these symptoms (most commonly auditory hallucinations) can be part of the expression of a psychotic illness, on their own they are neither necessary nor sufficient for a diagnosis. In fact, researchers from many countries [read the full story…]

Psychiatric comorbidity increases the risk of premature mortality in epilepsy

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There is a back to school feeling in the air in the Woodland this week, and so this comes to you with the help of my shiny new yellow pencil case. Epilepsy affects around 70 million people around the world and premature mortality is substantial with almost half of epilepsy-related deaths occuring in those younger [read the full story…]

It’s not the combat, maybe it’s the drinking in vulnerable young men

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A cohort study published in JAMA tried to answer the question what are the risk factors for suicide in the US military. This is a hot topic as the rate of suicide has increased in US military personnel from about 11/100,000 people in 2005 to about 18/100,000 so that now deaths from suicide outnumber deaths [read the full story…]

Tricyclic antidepressants are associated with higher risk of bone fracture

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While most people would likely associate tricyclic antidepressants (TCAs) with more common adverse effects such as dry mouth, sedation and constipation, there is some evidence to suggest increased occurrence of bone fractures (Vestergaard, Rejnmark, & Mosekilde, 2006). However, the topic remains controversial and conflicting results about the association of TCAs and fracture risk abound (e.g. [read the full story…]

Mortality rates amongst drug users in relation to time after hospital discharge

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People with substance misuse problems often present to services with complex physical and mental health needs.  Studies in the UK have indicated that common mental health problems are the norm in people in treatment for substance misuse. Weaver et al (2003) found 70% of people in treatment for substance misuse in London also had a [read the full story…]

Foetal exposure to sodium valproate is linked with autism risk

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The risks of congenital malformations and impact of cognitive development after foetal exposure to anti-epileptic drugs has been known for some time. Sodium valproate is a frequently used drug for epilepsy and other disorders (including bipolar disorder and migraine). The researchers aimed to examine the link between foetal exposure and subsequent development of autism. Methods [read the full story…]

Inappropriate use of antipsychotics to treat behavioural and psychological symptoms of dementia is likely to be more prevalent in care homes and low-income households

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Antipsychotics were discovered as an effective treatment for schizophrenia in the 1950s, but their use was expanded despite lack of supporting evidence, to treat other patient groups.  This included treating aggression, agitation and other behavioural and psychological symptoms of dementia (BPSD). There is evidence that these distressing symptoms can often be prevented or managed without [read the full story…]

The cardiovascular safety of dementia medications: a cross national study

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Two of the most widely available medicines for dementia in the UK are cholinesterase inhibitors and a N-methyl-D-aspartate (NMDA) receptor antagonists (NHS, 2013).  Both drugs are popular because they have been found to lead to improvements in dementia symptoms (Raina 2008). However, some have raised concerns about the safety for patients. These concerns are partly [read the full story…]

Short-term recovery from mild cognitive impairment is possible, but an increased risk of further cognitive decline remains

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The symptoms of mild cognitive impairment (MCI) include problems with cognitive functioning such as day-to-day memory. In some individuals it is the first sign of dementia, whereas in others it may be due to resolvable factors such as being the side-effect of medication (Alzheimer’s Society, 2012). At present it is unclear how many people with [read the full story…]

Do folic acid supplements in pregnancy prevent autism in children? A new cohort study suggests there is a link but more evidence is needed

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For many mums-to-be it is advised that taking regular folic acid supplements during pregnancy, and whilst trying to conceive, has significant health benefits for their unborn baby, namely around reducing the risk of neural tube defects such as spina bifida (NHS, 2013). However, do these supplements also affect the risk of the unborn baby developing [read the full story…]