10 randomised trials were included in this review of he adjunctive use of statins with scaling and root planing for treatment of chronic periodontitis . The findings suggest additional benefits with their use regardless of health or smoking status.
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Mark-Steven Howe looks at a systematic review of the effectiveness of adjunctive antibiotics in smokers undergoing non-surgical periodontal treatment. While a statistical benefit was noted it was not considered to be clinically relevant.
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This reviews of the efficacy of periodontal maintenance treatment carried out in primary care compared to the specialist setting following specialist treatment included 8 cohort studies. The quality of the available evidence was limited suggesting outcomes may be poorer in primary care further high quality studies are required
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This review of periodontal regeneration therapies included 52 trials. While the results suggest some statistically significant improvements they may not be clinically important. There is also limited data for outcomes longer than 12 months.
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Mark-Steven Howe looks in detail at a recent network meta-analysis (NMA) of periodontal outcomes following third molar surgery. However the limited number of studies available for the NMA mean the reviews findings need to be interpreted with caution.
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8 small RCTs were identified for this review of the effect of flap design on periodontal outcomes following third molar removal. The available evidence did not favour any particular flap design.
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This review of probiotics use for caries and periodontal disease management identified 50 studies. Most focused on surrogate outcomes (bacterial counts) and the overall quality of the evidence supporting probiotic therapy was graded as very low for all outcomes.
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This review of the adjunctive use of amoxicillin and metronidazole with scaling and root planing for the management of periodontitis found improved clinical outcomes in terms of pocket depth and clinical attachment level with their use.
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This review of platelet-rich plasma for intrabony periodontal defects included 21 studies. These were mainly small studies with a marked degree of heterogeneity. They suggest some potential benefits but the findings should be interpreted with caution.
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