This Cochrane review update of interventions for the prevention or treatment of medication-relatesd osteonecrosis of the jaw (MRONJ) included 13 RCTs. However the studies provided insufficient to either claim or refute a benefit of the interventions tested for prophylaxis or treatment of MRONJ.
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This review of the the frequency of osteonecrosis of the jaw in bisphosphonate users undergoing dental interventions included 27 studies. having dental procedures of 2.7% (95%CI: 0.9 to 5.2%) being higher in those having dental extractions 4.1% (95%CI: 1.5 to 7.7%).
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15 systematic reviews were included in this review of teh treament and management of medication-related osteonecrosis of the jaw (MRONJ). The reviews only identified weak evidence to support treatment protocols for MRONJ so high quality well reported RCTs are needed.
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This Cochrane review of interventions for the prevention and treatment of medication-related osteonecrosis of the jaw (MRONJ) identified 5 trials. Three were related to prevention and two to treatment providing limited evidence to support interventions. More high quality studies are needed.
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This Cochrane review of bisphosphonate related osteonecrosis of the jaw only identified one small RCT. The trial compared the use of hyperbaric oxygen (HBO) as an adjunct to standard care. While it suggested a benefit for HBO it was under powered and at high riisk of bias
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Thirteen studies were included in this review of medication related osteonecrosis of the jaw. The majority were case series ( 9) with the risk of osteonecrosis after tooth extraction being higher in those taking IV bisphosphonates ( 3.2% (95% CI: 1.7–4.7%) than those on oral bisphosphonates 0.15% (95% CI: 0.0–0.36%).
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97 papers describing 4879 cases of bisphosphonate-related osteonecrosis were included in this review. A wide range of management approaches were identified but the quality of the available evidence is limited.
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This 2 year long prospective study of new cases of BRONJ presenting at oral surgery, oral medicine, oral and maxillofacial surgery units, and dental hospitals provides a rough estimate of 508–793 new cases/year across the UK.
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