New systematic review shows how the incidence of schizophrenia and other psychoses has changed since 1950

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This is one in a series of 5 systematic reviews commissioned by the Department of Health, which seek to establish a comprehensive understanding of the distribution and pattern of psychotic disorders in England, between 1950 and 2009. All mental health professionals, commissioners and health planners will find this research relevant to their work. It’s well [read the full story…]

The side effects of lithium: new systematic review provides toxicity profile

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Lithium is a medicine that has been used for over 50 years to treat depression and bipolar disorder. It comes in two forms that are used clinically: lithium carbonate and lithium citrate. A certain level of the drug is needed in the blood stream for it to be effective, but if the level rises too [read the full story…]

Depressed patients who respond poorly to antidepressants are significantly more likely to develop bipolar disorder, says new cohort study

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Bipolar disorder is a complex health condition and the diagnosis of bipolar depression is a fairly contentious topic. This is because depression occurs in bipolar disorder alongside a wide range of symptoms of mood elevation. Some patients have depressive episodes as well as severely elevated mood during the course of their illness, whereas other patients [read the full story…]

Mental illness following childbirth can help predict bipolar disorder in later life

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We know that it can take many years for people with bipolar disorder to be accurately diagnosed, following an initial episode of mental illness. This cohort study carried out by researchers from Denmark, the US and Wales, set out to study to what extent psychiatric disorders with postpartum onset (following childbirth) are early manifestations of [read the full story…]

Should we be prescribing antipsychotics to young people with bipolar disorder?

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This systematic literature review and meta-analysis conducted by researchers from the University of Nebraska Medical Center, will be of interest to all clinicians who treat paediatric bipolar disorder. Treatment decisions for young people have previously been based on extrapolation from adult trials, case reports, open label trials or expert opinion. This new study provides a [read the full story…]

Creativity is associated with mental disorder, says new study

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New research shows people with bipolar disorder (and siblings of people with schizophrenia and bipolar disorder) are more likely to work in creative professions. The study, published in the November issue of the British Journal of Psychiatry, lends further support to the commonly-held view that creativity is associated with mental disorder. Researchers from the Karolinska [read the full story…]

New guidance on aripiprazole as a treatment for bipolar mania

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Aripiprazole (brand names Abilify and Aripiprex) is an atypical antipsychotic drug used to treat a number of mental health disorders including schizophrenia, depression and bipolar disorder. This new guidance has been written by a group of Pan-European experts who have come together to review new clinical guidelines for the management of mania and the role of aripiprazole [read the full story…]

The reasons for alcohol misuse in bipolar disorder: a systematic review

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Alcohol misuse is common in people with mental health problems and the rates of drinking are particularly high in bipolar disorder. Studies show that the lifetime prevalence of substance use disorders is at least 40% in bipolar I patients (ref Cerullo et al). Researchers from Newcastle University in the UK have conducted a systematic review [read the full story…]

Tooth loss three times higher in people with serious mental illness

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People with severe mental illnesses like schizophrenia or bipolar disorder are over three times more likely to lose their teeth because of poor oral health than the general population. The research, published in the September issue of the British Journal of Psychiatry, shows that psychiatric patients have not shared in recent improvements in dental health. [read the full story…]

Major new meta-analysis shows that antipsychotics are significantly more effective than mood stabilisers for treating acute mania

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Researchers from Oxford and Verona have published a major new meta-analysis in the Lancet, which measures the effectiveness of all anti-manic drugs. The review team searched and found 68 randomised controlled trials from 1980-2010 (a total of 16,073 patients).  The study includes a range of antipsychotics and mood stabilisers used at a therapeutic dose range [read the full story…]