There is a need for a rapid-acting, non-injection, acute treatment for agitation in people with schizophrenia. This randomised (double-blind, placebo-controlled, parallel-group) controlled trial set out to evaluate the effectiveness and safety of inhaled loxapine for acute treatment of agitation in schizophrenia. The researchers recruited 344 adults with DSM-IV schizophrenia who were in good general health [read the full story…]
The Dementia Commissioning Pack provides practical resources for health and social care commissioners to work together to improve the quality of both specialist dementia services and general health and care services for people with dementia and their carers. The pack has been developed in consultation with a range of health and social care experts, including [read the full story…]
Antipsychotics are widely used for the management of behavioural problems in people with learning disability, despite concerns about the lack of a good evidence base for this practice (see Cochrane review) The researchers in this study set out to audit clinical practice of prescribing anti-psychotics against standards of good practice. The authors collected data from [read the full story…]
Many people with bipolar disorder have a range of therapies available to them nowadays, including mood stabilisers (or anticonvulsants), antipsychotics and various psychosocial interventions (including CBT, psychoeducation and family therapy). A research team from the University of Barcelona have published a meta-analysis that investigates the efficacy of drug maintenance treatments for bipolar disorder. They searched from [read the full story…]
Antipsychotic medication is widely used to treat behavioural problems in people with learning disabilities. A Cochrane review of the use of these medications for this purpose found very few randomised controlled trials (a method of clinical research in which people are allocated at random to receive a clinical intervention, a placebo, or no intervention at [read the full story…]
Many people with schizophrenia struggle to adhere to their oral antipsychotic drug regimen. It is thought that depot antipsychotic drugs (a special preparation of the medication, which is given by injection and is slowly released into the body over a number of weeks) may reduce relapse rates by improving adherence. This systematic review searched for randomised controlled [read the full story…]
Anti-psychotic medications comprise between 30–50% of all psychotropics prescribed for people with learning disabilities as reported in this WELD post: This study set out to explore metabolic syndrome (a group of risk factors that occur together and increase the risk for coronary artery disease, stroke and type 2 diabetes in people with learning disabilities who [read the full story…]
Many published guidelines (including the American Psychiatric Association Clinical Practice Guidelines for schizophrenia), recommend second-generation antipsychotics for the treatment of depression in schizophrenia. This study compared a first-generation antipsychotic (perphenazine) with 4 second-generation antipsychotics (olanzapine, quetiapine, risperidone, and ziprasidone) and the impact these drugs had on the symptoms of depression. The authors used data from the Clinical [read the full story…]
This care recommendation produced by Drew H. Barzman (Assistant Professor of Pediatrics and Psychiatry at Cincinnati Children’s Hospital Medical Center) sets out to answer the following question: Among children with ADHD and aggression, is the pharmacological treatment of ADHD, versus no pharmacological treatment of ADHD, effective in reducing aggressive behaviour? The authors searched Medline, PsychInfo, the National Guidelines [read the full story…]
Valproate is widely used as a mood stabiliser for people with bipolar disorder, despite the fact that there is very little evidence that shows the effectiveness of this treatment. This observational cohort study looked at over 4,000 bipolar patients in Denmark who were treated with lithium or valproate from 1995 to 2006. The results favoured [read the full story…]
