Long-acting antipsychotics cost-effective for treatment of schizophrenia, but evidence inconsistent

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Here at Mental Elf HQ we’re expanding our skill set to include economics. Understanding the best way to value health and health care, and improving health outcomes with budget constraints in mind, are the key pastimes of economics elves. We hope to bring you the latest economic evidence in the field of mental health and to [read the full story…]

Inappropriate use of antipsychotics to treat behavioural and psychological symptoms of dementia is likely to be more prevalent in care homes and low-income households

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Antipsychotics were discovered as an effective treatment for schizophrenia in the 1950s, but their use was expanded despite lack of supporting evidence, to treat other patient groups.  This included treating aggression, agitation and other behavioural and psychological symptoms of dementia (BPSD). There is evidence that these distressing symptoms can often be prevented or managed without [read the full story…]

Old side effects and old drugs; old side effects and new drugs

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People using antipsychotic drugs like chlorpromazine and haloperidol get [anticholinergic] side effects such as blurred vision, dry mouth and constipation but the proportion of people experiencing these is not clear. Past surveys are very old indeed, small and not really proper surveys at all. Their results had been perpetuated for decades without verification. They were [read the full story…]

German cohort study finds no support for superiority of atypical antipsychotics in schizophrenia

It is possible that those who were disengaging from interventions such as medication were less likely to take part in the study.

Schizophrenia according to the NICE guidelines, is a relatively common illness and in the majority of cases takes a chronic course, requiring continued management and careful attention.  In the treatment and management of schizophrenia, antipsychotic medications – like olanzapine, quetiapine or clozapine – are the first line intervention. Antipsychotics can be loosely divided into “first-generation” (“typical”) and [read the full story…]

Parents and caregivers of people with Williams syndrome rate benefits from medications in reducing anxiety

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Williams syndrome is a neuro-developmental genetic disorder caused by gene deletion estimated to have a prevalence of 1 in 7,500 to 1 in 20,000 live births. Previous studies have identified anxiety as part of the behavioural phenotype of the syndrome The authors of this US study set out to look at the effectiveness and adverse [read the full story…]

Individual CBT, with or without family CBT, could be the best first line treatment for people at high risk of schizophrenia

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Schizophrenia is a debilitating illness that affects an estimated 25 million people worldwide. People with the condition can experience a huge amount of disability (both social, physical and psychological), but we know that early intervention can help reduce the duration of the illness and prevent further episodes of relapse. People with schizophrenia usually experience a [read the full story…]

NICE publish first guideline for psychosis and schizophrenia in children and young people

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Everyone who read the extracts from Michael Schofield’s memoir, published by the Guardian on January 19th, must surely have been moved by the sometimes harrowing description of his daughter Janni who was diagnosed with child-onset schizophrenia aged just 7 years old. Janni is an exception, as schizophrenia generally starts between the ages of 15 and [read the full story…]

NICE publish new evidence summary on psychosis with coexisting substance misuse

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The NICE guideline on psychosis with coexisting substance misuse was published in 2011, which means it’s now nearly 3 years out of date. This is because guidelines take many months to produce, so by the time they are published the evidence in them is 1 year old at best. Some NICE guidelines are supplemented by [read the full story…]

Check out the new BITE-sized mental health summaries from the NIHR CLAHRCs

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Anyone who’s spent any time at all on the Mental Elf website, or any of the other National Elf Service sites, knows that we elves love succinct and focused summaries that are easy to read and quick to digest. It’s always a delight to see other groups publishing similar resources, so I’ve decided today to [read the full story…]

Antipsychotics don’t help increase weight or reduce symptoms for women with anorexia nervosa

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Evidence-based treatments for mental health conditions have come on in leaps and bounds in the last 20 years. I remember as a young elf, skipping around the country and running workshops on evidence-based mental health; training psychiatrists, psychologists, nurses and others. There wasn’t much gold standard evidence to choose from back then and there was [read the full story…]