This review of the comparative efficacy of interventions used for the treatment of denture stomatitis(DS) included 35 RCTs with 25 studies contributing to the meta-analyses. The findings suggest that topical antifungal agents produced the most effective clinical improvement and microwave disinfection and topical antifungals the best mycological resolution. Only one of the RCTs was at low risk of bias so the findings should be interpreted cautiously.
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This review comparing the efficacy and safety of topical antifungal drugs for oral candidiasis in children and adults included 11 RCTs 9 of which concerned adults and 2 children. The findings support the use of fluconazole and amphotericin B for adults.
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This review of comparing photodynamic therapy (PDT) and antifungals or the treatment of denture stomatitis included 5 studies involving a total of 218 patients. While the findings suggest that PDT is effective none of the the studies was at low risk of bias and the treatment protocols investigated differ.
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This review comparing topical natural substances with conventional antifungals in the treatment of denture stomatitis included 17 studies 14 of which were RCTs. A wider range of natural products were tested and showed similar efficacy to antifungals however, almost all the studies were at high risk of bias so the certainty of the evidence is very low.
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This review of the effectiveness of removable complete denture disinfection using microwaves for the treatment of denture stomatitis included 3 small RCTs. While the findings suggest that microwave may be effective the evidence is of low certainty so additional high quality well reported studies are needed.
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This network meta-analysis of the efficacy of antifungal drugs on oral candidiasis included 31 RCTs of overal low quality suggesting that fluconazole may be the most effective.
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This review of low-level laser therapy (LLLT) or photodynamic therapy (PDT) in the treatment of denture stomatitis only identified 4 small RCTs providing limited low quality evidence of clinical effectiveness.
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Denture stomatitis is relatively common with studies suggesting that it can affect 35-50% of complete denture wearers. It is characterised by mild inflammation and redness of the oral mucosa and about 90% are associated with Candida. The aim of this review was compare the efficacy of antifungal therapy with any other alternative methods used for [read the full story…]
