There is evidence from epidemiological studies that low levels of zinc are associated with depression, but good quality clinical trials that explore the link between zinc supplementation and depression are few and far between. This systematic review conducted by a research team from the University of Newcastle in New South Wales, Australia, aimed to synthesise results from [read the full story…]
There are a number of cross-sectional studies that investigate antidepressant use in teenagers and young adults. These are interesting, but because they don’t tend to follow-up study participants prospectively over a long period of time, there is only so much we can learn from them. However, now researchers in Finland have published a study that [read the full story…]
Researchers from the VU University in Amsterdam and the EMGO Institute have published a nice summary of the effects of psychotherapies for adult depression. The study summarises a series of meta-analyses that they have carried out, to measure the strength of the evidence for the different types of psychotherapy in treating different types of depression. Here’s what [read the full story…]
Depression is common in patients with dementia and antidepressants are widely prescribed for this population although the evidence remains limited. This randomised controlled trial conducted by researchers at the Institute of Psychiatry in London and published in the Lancet, explored the safety and efficacy of two widely-used drugs (sertraline and mirtazapine) in patients with dementia and [read the full story…]
This cohort study conducted by researchers from the St. Louis Veterans Affairs Medical Center set out to answer the question: Are antidepressants associated with an increased or decreased risk of incident myocardial infarction and all-cause mortality? 93,653 patients aged 25–80 years (average age 51.5 years, 14.1% female, 77.8% White, 57.1% not married) were identified using the [read the full story…]
The manufacturer of agomelatine (Servier) has informed NICE that it would not be making an evidence submission for the appraisal of agomelatine for the treatment of major depressive episodes. Servier drew attention to the fact that NICE guidelines for England and Wales recommend generic selective serotonin reuptake inhibitors (SSRIs) as first-line treatment followed by a [read the full story…]
Teenagers with depression sometimes do not respond to treatment with SSRI antidepressants and this inevitably leads to a higher cost of treatment. This randomised controlled trial (conducted by researchers from Kaiser Permanente Northwest in Portland, Oregon) set out to evaluate the incremental cost-effectiveness over 24 weeks of combined cognitive behavior therapy plus switch to a different antidepressant [read the full story…]
A research team from the University of Bologna in Italy have published a new meta-anlaysis that explores the sequential integration of psychotherapy and pharmacotherapy in reducing the risk of relapse and recurrence in major depressive disorder. They searched a range of databases for randomised controlled trials that tested the efficacy of the administration of psychotherapy after successful [read the full story…]
It can be hard to detect and treat depression when it occurs in palliative care because it often presents amongst a multitude of other symptoms. There are obviously many systematic reviews that assess the use of antidepressants as a treatment for various life threatening illnesses, but no previous study has synthesized the evidence in palliative [read the full story…]
A large observational study from Finland has found that women who drink alcohol and take selective serotonin reuptake inhibitor antidepressives (SSRI) during the first trimester of pregnancy significantly increase their risk for foetal alcohol spectrum disorders. The study also found an increase in risk for some major congenital malformations associated with the use of SSRIs during the first [read the full story…]
