One of the major complaints of people on antidepressant medication is the effect it has on their sex lives. It does this in three main ways – it affects sexual desire, the ability to achieve and sustain an erection in men and alters the sensation of orgasms and ejaculation. These side effects are one of [read the full story…]
Meta analysis of antidepressants vs talking therapies: another example of ‘All Must Have Prizes’?
Patients presenting to their GP with a mental health problem are likely to be offered medication, in the form of antidepressants, and/or a ‘talking therapy’, such as counselling or CBT. This is because we know that both those broad categories of treatments (drugs and psychological therapies) are effective in reducing symptoms. However, it’s less clear [read the full story…]
Systematic review finds that tricyclics do not benefit children with depression
Clinical depression is one of the most common mental health problems occurring in children and adolescents. It is often accompanied or followed by additional negative outcomes, including social and academic problems, anxiety and substance use. Many depressed adolescents continue to have recurring problems throughout adulthood. A variety of antidepressant drugs, such as tricyclics and selective [read the full story…]
Observational study: antidepressant suicidality warnings may be counterproductive
Selective serotonin reuptake inhibitors (SSRIs) have long been suspected to – paradoxically- increase suicidal behaviour in adolescent and pediatric patients. Consequently, national watchdogs started issuing black label warnings for all SSRIs to educate physicians and patients about associated risks. While clearly curbing the amount of antidepressant prescriptions, concerns have been voiced that this step has [read the full story…]
Transcranial magnetic stimulation (rTMS) enhances response to antidepressants: a rather flawed meta-analysis
It’s a well-known fact that elves are allergic to unhappiness, so the fact that there are at least 350 million sufferers of depression worldwide1 is quite a problem. That’s before we’ve even mentioned the crippling mortality, morbidity and economic impact that depression causes. The trouble is, our treatments for depression aren’t perfect. Less than a [read the full story…]
Cost effectiveness analysis finds stepped care to be cheaper and more effective than CBT for bulimia nervosa
Bulimia nervosa (BN) is an eating disorder; the diagnosis of which requires: persistent preoccupation with eating and an irresistible craving for food, episodes of overeating in which large amounts of food are consumed over a short period of time and potentially attempts to counteract the “fattening” effects of food by self-induced vomiting or laxative abuse. [read the full story…]
Treatment of depression after a heart attack does not improve the long-term risk of adverse cardiac events but may increase survival
Although there have been huge advances in the treatment of heart disease, it is still the UK’s biggest killer (more information on heart disease can be found at the British Heart Foundation’s website). Depression after a heart attack is common (roughly 20% prevalence) and can worsen heart disease and increase the risk of death. A [read the full story…]
Maternal antidepressant use in pregnancy may be associated with a small increased risk of autism
The prevalence of autistic spectrum disorders has risen dramatically in the last thirty years, with recent estimates suggesting that 1 in 88 children in the United States have an autistic spectrum disorder. This increasing prevalence could simply be due to changes in the diagnosis of such disorders and so be of little interest. However, there [read the full story…]
The latest evidence from NICE on depression in children and young people
The NICE guideline for depression in children and young people was published way back in September 2005. Any elf worth his salt will tell you that a whole heap of evidence has been published since then, so it’s good to see an evidence update appear this week from NICE, which brings together research published from 17th [read the full story…]
SSRIs and TCAs are equally effective at treating chronic depression, but SSRIs have fewer side effects
Major depression all too often develops a chronic course, with every episode making future relapse more likely (Gilmer et al., 2005). Dysthymic disorders represent a less severe, but more persistent form of depression lasting for at least two years. In the affective disorder spectrum, chronic forms are unsurprisingly associated with greater functional impairment and overall [read the full story…]