Postpartum haemorrhages are serious birth complications that represent one of the leading causes of maternal mortality and morbidity. While incidences of postpartum haemorrhages have risen steadily in the past decades (in the US alone, numbers increased from 2.3% to 2.9% from 1994 to 2006), there is little evidence as to why. Antidepressants – especially selective [read the full story…]
Cognitive-behavioral therapy (CBT) is widely researched and recommended as an evidence-based treatment for adult depression, but despite the strength of research comparing CBT approaches with other forms of care, there are few recent systematic reviews on this topic. Cuijpers and collaborators provide such a review in a recent meta-analysis published in The Canadian Journal of [read the full story…]
Depression is common in primary care and associated with a substantial personal, social and societal burden. There is considerable ongoing controversy regarding whether antidepressant pharmacotherapy works and, in particular, for whom. One widely-prescribed antidepressant is fluoxetine (Prozac), an antidepressant of the selective serotonin reuptake inhibitors (SSRI) class. Although a number of more recent antidepressants are [read the full story…]
Hospitals are supposed to make people better, not worse – so hospital-acquired infections are always a big topic. Clostridium difficile infection (CDI) is the most commonly diagnosed cause of antibiotic-associated diarrhoea, and causes more than 7,000 deaths each year in the US alone. There have been studies into risk factors for CDI, one of them [read the full story…]
Around 20% of adults in the UK smoke cigarettes regularly. Smoking was the primary cause of approximately 462,900 hospital admissions and 79,100 (18%) deaths in adults over the age of 35 last year. Therefore, smoking cessation represents a serious (and costly!) clinical challenge on an individual and global level. Many smoking cessation aids are available, [read the full story…]
Obsessive compulsive disorder (OCD) is a condition that has recently been given a significant amount of TV airplay and media coverage, perhaps most notably in the Channel 4 documentary Jon Richardson: A little bit OCD, which received mostly good reviews from mental health groups. Despite this reasonable public profile, our knowledge about the best way [read the full story…]
Some mental health interventions feel intuitively right. Exercise for depression is a great example. Of course, people suffering from low mood, poor motivation, lethargy and all of the other symptoms of depression will benefit from a jog around the park and some fresh air, right? The logical explanation for how this might help is fairly [read the full story…]
Meta-analyses are an incredibly useful tool for synthesising evidence. However, such analyses typically use aggregate data, meaning the average scores or outcomes for treatment groups, which can cause problems if we’re trying to dig a little deeper into the question of ‘what works’ to answer ‘what works, and for whom?’ The ‘for whom?’ question is [read the full story…]
While most people would likely associate tricyclic antidepressants (TCAs) with more common adverse effects such as dry mouth, sedation and constipation, there is some evidence to suggest increased occurrence of bone fractures (Vestergaard, Rejnmark, & Mosekilde, 2006). However, the topic remains controversial and conflicting results about the association of TCAs and fracture risk abound (e.g. [read the full story…]
A major challenge in the treatment of depression is that only a proportion of people respond to the first treatment they try. For example, with antidepressants only 40% of people will see their symptoms fall to a level that can be considered a recovery. Trying further treatments after the first one does not work can [read the full story…]
