Antidepressants for depression: new BAP guidance

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Helge Hasselmann summarises the recently published evidence-based guidance on antidepressants for depression published by the British Association for Psychopharmacology.

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Combined methylphenidate and citalopram may help older people with depression recover faster

Depressed older man

Lisa Burscheidt summarises a recent randomised controlled trial of combined methylphenidate and citalopram for depression in older people, which presents promising but limited findings.

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Antidepressants for depression in cancer: Cochrane review highlights lack of evidence

Female cancer patient

Kirsten Lawson reports on a recent Cochrane systematic review, which highlights a lack of high quality trials about the efficacy and safety of antidepressants for depression in cancer.

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Medication for self-harm: new Cochrane review finds very limited evidence to support its use

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Dochka Hristova reports on a new Cochrane review of pharmacological interventions for self-harm in adults, which looks at the treatment effect on repetition of self-harm of antidepressants, antipsychotics, mood stabilisers and dietary supplements.

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Treatments for delusional disorder

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Andrew Shepherd summarises a Cochrane systematic review of treatments for delusional disorder, which finds only 1 small RCT looking at treating the condition with medication or psychotherapy compared to placebo.

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Antidepressants during pregnancy and risk of persistent pulmonary hypertension of the newborn

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Meg Fluharty examines the findings of a recent study, which looks at the risk of persistent pulmonary hypertension of the newborn (PPHN) when mothers take antidepressants during pregnancy.

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Pharmacotherapy for anxiety and comorbid alcohol use disorders

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Natasha Clarke summarises a recent Cochrane review of pharmacotherapy for anxiety and comorbid alcohol use disorders, which found only very low quality evidence about the effectiveness of medication (buspirone, paroxetine, sertraline) for treating patients with both conditions.

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Dose equivalents of antidepressants: standardising prescribing between different drugs

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Andrew Shepherd summarises a meta-analysis, which looks at the dose equivalents of antidepressants by bringing together data from 83 trials of 23 different antidepressants.

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Pharmacotherapy for PTSD: an update on the evidence finds some efficacy but small effect sizes

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Patrick Kennedy-Williams summarises a recent systematic review of pharmacotherapy for PTSD, which compares antidepressants with placebo for post-traumatic stress disorder. [Please note: this blog was amended on 7/5/15].

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Mindfulness-based cognitive therapy to prevent depression

In April 2015 we blogged PREVENT and concluded that mindfulness based cognitive therapy is a promising intervention for preventing depression.

André Tomlin presents the results of the PREVENT RCT published today in The Lancet, which investigates the effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence.

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