This review estimating the nocebo response in dentistry from trials of analgesic treatment following third molar surgery included data from 50 RCTs. Adverse events (AEs) were roughly the same in placebo and active arms suggesting AEs may be attributed to the nocebo phenomenon.
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This review of the efficacy of oxycodone for post-operative acute dental pain included 13 studies. the findings showed that NSAIDs are generally superior for post-surgical dental pain, with a better adverse effect profile,so the need for oxycodone in dentistry is limited.
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This Cochrane review update comparing single and multiple vist root canal treatments in patients over the age of 10 included 47 RCTs. There was no evidence to suggest that one treatment regimen (single‐visit or multiple‐visit RoCT) is more effective than the other although more patients report pain in the first week with the single visit approach.
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This review assessing the risk of alveolar osteitis (AO) in in oral contraceptive users included 17 mainly observational studies. The findings showed an increased risk of developing AO in female oral contraceptive (OCP) users, RR = 1.98 (95%CI:1.42 to 2.76) compared to female non-OCP users
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This review of the effect of pre-emptive ibuprofen on post-operative pain after lower third molar surgery included 5 RCTs. Only one of the included studies was at low risk of bias so there is insufficient evidence to support the routine use of pre-emptive ibuprofen to reduce post-operative pain after lower third molar removal
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This review evaluating clinical efficacy of analgesics in mitigating orofacial pain following dental implant surgery included 9 RCTs. While the findings suggest analgesics may be beneficial the number of studies is small an additional infromation is required on which medication,, dosage, dosing schedule, administration route and adverse effects.
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This review of different methods for reducing pain and discomfort during removal of fixed orthodontic appliances included 6 RCTs providing weak evidence for pre-debonding analgesia and other approaches.
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17 studies, none of which were at low risk of bias, were included in this review of the effect of type of instrumentation on post endodontic pain. The findings suggest lower incidence and intensity of postoperative pain with rotary instruments compared to hand files.
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This review of non-pharmacological intervention to reduce mental distress, pain, and analgesic use in adults undergoing dental treatment included 29 RCTs. The findings suggest positive benefits for the interventions examined with no significant differences between the various interventions.
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This review of the use of non-steroidal anti-inflammatory drugs (NSAIDs) for the management of post endodontic pain demonstrates that they do help to manage the pain.
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