This review and network meta-analysis of seven treatments for white spot lesions (WSLs) included 36 clinical RCTs published since 2007. The findings suggest that self-assembling peptide P11-4 and resin infiltration had a positive effect on WSLs but the findings should be interpreted cautiously.
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This overview of systematic reviews of evidence for the prevention of enamel demineralization during fixed appliance orthodontic treatment included 29 reviews. Most of the reviews were considered to have methodological issues with the findings suggesting that professional fluorides, sealants, reminders, and lasers might be useful interventions to prevent enamel demineralization.
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