This review of the adjunctive effect of statins on mechanical periodontal therapy included 15 studies 12 of which were RCTs. The findings suggest a positive effect on probing pocket depth, clinical attachment level, and intrabony defects but the overall quality of evidence is considered to be low.
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This review of adjunctive use of systemic antibiotics in nonsurgical periodontal treatment of diabetics identified 12 small RCTs. No additional benefit was seen with antibiotic use
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This reviews of the efficacy of periodontal maintenance treatment carried out in primary care compared to the specialist setting following specialist treatment included 8 cohort studies. The quality of the available evidence was limited suggesting outcomes may be poorer in primary care further high quality studies are required
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7 prospective cohort studies were included in this review of dental implant survival in patients with periodontitis. Patients with aggressive periodontitis has statistically significant lower survival rates at 3 years but the quality of the evidence is limited.
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This review of systemic antibiotics and non-surgical periodontal therapy for aggressive periodontitis included 13 RCTs and suggests a statistically significant benefit compared to non-surgical therapy alone.
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This review of azithromycin as an adjunct to scaling and root planing for periodontal disease included 9 small RCTs. While some studies demonstrated some small improvements in periodontal parameters, there was no data to demonstrate superiority of azithromycin against the standard antibiotic combination of metronidazole and amoxicillin.
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This review looked at the effectiveness of antimicrobial photodynamic therapy as an adjunctive treatment to scaling and root polishing for aggressive periodontitis. Seven small studies suggest that it may be beneficial in the short term.
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This review and network meta-analysis included 11 small RCTs of limited quality, suggesting a statistically significant benefit for the use of adjunctive systemic antibiotics for the treatment of aggressive periodontitis.
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This review included 17 studies and 843 patients. A wide range of cytokines/chemokines were assessed but the available evidence is not sufficient to prove that there are distinct differences between patients with aggressive periodontitis and those with chronic periodontitis.
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Another review of failure rates of dental implants shows increased failure rates in patients with generalised aggressive periodontitis. Six studies (5 from the same research group ) involving 290 patients and 834 implants were included.
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