Flo Martin summarises a recent umbrella review which finds that we still have limited knowledge about the safety of psychotropic drug use in pregnancy.
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Gemma Lewis and Glyn Lewis summarise a robust systematic review and meta-analysis investigating the incidence of symptoms when discontinuing or withdrawing from antidepressants. The data suggest that 8-14% of patients will experience antidepressant discontinuation symptoms, and for around 2% these symptoms will be severe.
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Michael Kalfas and Paul Leeks summarise a recent Danish study that assesses the risk of antidepressant-induced mania in patients with bipolar depression.
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This review comparing the effectiveness of articaine and lidocaine for lower third molar surgery included 14 RCTs. The findings suggest that articaine is superior to lidocaine for use in lower third molar however the available are small so additional larger high quality studies would be helpful to strengthen the evidence.
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This review of the effects and adverse reactions between articaine and lidocaine in paediatric dental procedures included 8 RCTS. Three of the included studies were at high risk of bias 2 at low risk and 3 at unclear risk. The findings suggested no difference in adverse effects between the two anaesthetics with the certainty of evidence being assessed as moderate.
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Caroline Touzeau and Caitlin Lloyd blog about a recent longitudinal cohort study that investigated patterns of maladaptive exercise in young people, which supports “re-framing motivations for exercise in youth away from weight loss at a population level”.
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270 pateints were randomised in this trial to compare high-fluoride toothpaste and high-fluoride mouth rinse for preventing white spot lesions during orthodontic treatment. The findings suggest a benefit for high fluoride toothpaste and fluoride mouth rinse in preventing white spot lesions.
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In this blog, UCL MSc students consider an RCT published in the New England Journal of Medicine, which suggests that psilocybin-assisted psychotherapy may help reduce depression in people with severe and enduring illness, but side effects are common and more research is needed to look into longer term effects.
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This review of early versus delayed initiation of space closure after tooth extraction on the rate of orthodontic tooth movement included 11 RCTs. The findings suggest little difference between the two approaches but the included studies are small and none of the theam are at low risk of bias.
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Angharad de Cates reviews a recent Danish trial, which finds that escitalopram reduced participants’ reinforcement sensitivity compared to those on placebo. This lower reinforcement sensitivity may be similar to the emotional blunting effect often reported by patients during SSRI treatment.
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