Mary Butler explores a recent randomised controlled trial of probiotic formulations for patients with bipolar disorder or schizophrenia spectrum disorder.
[read the full story...]Probiotics for bipolar disorder and schizophrenia
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Non‐surgical procedures to accelerate orthodontic tooth movement
This Cochrane review update was to assess the effect of non‐surgical adjunctive interventions on the rate of orthodontic tooth movement and the overall duration of treatment included 23 RCTs.The findings suggest there may be limited benefit from photobiomodulation application for accelerating discrete treatment phases but this should be interpreted very cautiously as the findings may not be clinically important and the evidence is of low to very low certainty.
[read the full story...]Chlorhexidine chip as adjunct to scaling and root planing in patients with chronic periodontitis
This review of sub-gingival chlorhexidine chips as an adjunct to scaling and root planing in patients with chronic periodontitis included 15 RCTs involving 620 patients in total. Findings suggest an additional improvement with adjunctive use of chlorhexidine chips.
[read the full story...]Is Cannabidiol (CBD) an effective antipsychotic?
Luke Sheridan Rains publishes his debut blog on a recent multicentre RCT of Cannabidiol (CBD) as an adjunctive therapy for people with schizophrenia, which suggests that CBD had a beneficial, but modest impact on positive psychotic symptoms and severity of illness when used alongside existing antipsychotics.
[read the full story...]Periodontitis- supportive periodontal treatment
This Cochrane review of the effects of supportive periodontal therapy (SPT) in the maintenance of the dentition of adults treated for periodontitis included 4 RCTs providing is insufficient evidence to determine the superiority of different protocols or adjunctive strategies to improve tooth maintenance during SPT.
[read the full story...]Antidepressants for bipolar depression: weighing up the benefits and harms
Murtada Alsaif considers a recent systematic review on the safety and efficacy of adjunctive second-generation antidepressant therapy with a mood stabiliser or an atypical antipsychotic in acute bipolar depression.
[read the full story...]Adding antidepressants to antipsychotics in schizophrenia: do they work, for what, and are they safe?
Alex Langford explores the emerging findings from a recent meta-analysis looking at the efficacy and safety of antidepressants added to antipsychotics for people with schizophrenia and schizophrenia-like psychosis.
[read the full story...]Little research on non-surgical interventions to accelerate orthodontic treatment
With orthodontic treatment lasting typically 18-24 months, adjunts to accelerate tooth movements would be welcome. This Cochrane review identified two RCTs on non-surgical interventions to accelerate orthodontic treatment. However, both studies were at high risk of bias, so we cannot rely on their findings.
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