Nicotine replacement therapy – oral side effects

For inpatients with psychiatric symptoms of moderate severity, the study suggests those using nicotine inhalers were most successful overall in their quit attempts. There were no severe adverse reactions to the NRTs.

This review of the evidence on possible association between locally delivered nicotine replacement therapy(NRT) and oral side effects included 28 RCTs. Most of the RCTs were at high risk of bias mainly because of allocation concealment concerns. Reported oral side effects including oral soreness, gastric reflux or vomiting, and mouth or throat irritation.

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Schizophrenia and cannabis use: new evidence measures risk of relapse

Over 20% of cannabis users experience a psychotic relapse within 24 months of treatment.

In her debut blog, Sally Turner considers a recent study on cannabis use and clinical outcomes in people with first-episode schizophrenia spectrum disorders over 24 months of treatment.

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Do psychotherapies help children or adolescents with subclinical depression?

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David Hallford summarises a meta-analysis of psychotherapies for subthreshold depression, which suggests they may have positive acute effects in adolescents, but are not effective in children less than 12 years of age.

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New research suggests that youth suicide attempts can result in later-life economic and social disadvantages

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In her debut blog, India Bellairs-Walsh summarises a recent population-based cohort study investigating the long-term economic and social outcomes of youth suicide attempts.

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CAD-CAM removable complete dentures

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This review comparing the outcomes of , CAD-CAM removable complete dentures (CDs) with conventional CDs included 73 studies. A majority of the studies were in-vitro small, and involved multiple comparison. 39 studies contributed to meta-analyses of a broad range of parameters whiich suggest little technical difference between CAD-CAM and conventional CDs. However few studies reported on aesthetics or patient reported outcomes.

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Mindfulness in schools: MYRIAD trial findings offer limited support for school based mindfulness training

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Lucinda Powell reports on the findings of the huge MYRIAD (My Resilience in Adolescence) project, which looked at the effectiveness of school based mindfulness training across more than 100 UK schools.

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Review finds that violence against women and girls is exacerbated during and after natural disasters

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Anna Sri summarises a review which finds that violence against women and girls is exacerbated by natural disasters such as flooding, earthquakes or hurricanes.

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Tooth extraction prior to head and neck radiotherapy and osteoradionecrosis risk

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28 mainly retrospective studies were included in this review which aimed to determine if tooth extraction prior to head and neck radiotherapy (RT )is associated with a reduced risk of developing osteoradionectosis (ORN). The findings showed a significant association of post-RT dental extractions with the risk of ORN development, odds ratio = 1.98 (95%CI: 1.17 to 3.35. However the certainty of the evidence was low to moderate.

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HIV stigma and depression: new systematic review of people in South Africa

LANGA TOWNSHIP, SOUTH AFRICA - JULY 12, 2015 - A young girl poses for a photograph at her home in Langa, South Africa, a township located on the outskirts of Cape Town.

Rudo Dude summarises a systematic review which examines the links between HIV stigma and depression among people living with HIV/AIDS in South Africa.

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